Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications
Ionic liquid (ILs) self-assembled micelles (ILs-SAMs) are promising and effective drug delivery systems, which combine the merits of ILs and micelles. Herein, the properties, assembly, functions, and treatments of ILs-SAMs in transdermal drug delivery are summarized. This paper first reviews the fun...
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| Language: | English |
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Elsevier
2025-12-01
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| Series: | International Journal of Pharmaceutics: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156725000350 |
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| author | Ziqing Deng Shuwei Tang Mingjie Ou Zhuxian Wang |
| author_facet | Ziqing Deng Shuwei Tang Mingjie Ou Zhuxian Wang |
| author_sort | Ziqing Deng |
| collection | DOAJ |
| description | Ionic liquid (ILs) self-assembled micelles (ILs-SAMs) are promising and effective drug delivery systems, which combine the merits of ILs and micelles. Herein, the properties, assembly, functions, and treatments of ILs-SAMs in transdermal drug delivery are summarized. This paper first reviews the fundamental concepts, classifications, assembly mechanisms, characterization techniques, and functional roles of ILs-SAMs. ILs-SAMs are micellar structures formed by the self-assembly of ILs through different intermolecular interactions, and are affected by multiple environmental factors. They possess unique physicochemical properties, endowing them with high stability and effective drug carriers, which could regulate their compositions and structures for flexible and controllable characteristics. Next, the review demonstrates that ILs-SAMs offer remarkable advantages in transdermal delivery, including solubilization enhancement, permeation enhancement, and targeted transdermal delivery. It alters the surface tension and viscosity of permeating substances, facilitates transdermal drug penetration, and utilizes nanoscale properties for precise, targeted delivery. Remarkably, ILs-SAMs were compared with other ILs self-assembled nanoparticles (ILs-SANPs) and polymer micelles, and the former possessed superior properties, including easier self-assembly and higher stability. Lastly, it focuses on their applications in treating skin cancer, arthritis, diabetes, fungal infections, and skin photoaging. Collectively, the novel ILs-SAMs are multifunctional transdermal drug delivery systems used for permeation enhancement, targeted drug delivery and different skin disorders. |
| format | Article |
| id | doaj-art-948af65a2d1143918e4bcc58894b9f7b |
| institution | DOAJ |
| issn | 2590-1567 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj-art-948af65a2d1143918e4bcc58894b9f7b2025-08-20T03:16:08ZengElsevierInternational Journal of Pharmaceutics: X2590-15672025-12-011010035010.1016/j.ijpx.2025.100350Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applicationsZiqing Deng0Shuwei Tang1Mingjie Ou2Zhuxian Wang3School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, China; Corresponding author.Ionic liquid (ILs) self-assembled micelles (ILs-SAMs) are promising and effective drug delivery systems, which combine the merits of ILs and micelles. Herein, the properties, assembly, functions, and treatments of ILs-SAMs in transdermal drug delivery are summarized. This paper first reviews the fundamental concepts, classifications, assembly mechanisms, characterization techniques, and functional roles of ILs-SAMs. ILs-SAMs are micellar structures formed by the self-assembly of ILs through different intermolecular interactions, and are affected by multiple environmental factors. They possess unique physicochemical properties, endowing them with high stability and effective drug carriers, which could regulate their compositions and structures for flexible and controllable characteristics. Next, the review demonstrates that ILs-SAMs offer remarkable advantages in transdermal delivery, including solubilization enhancement, permeation enhancement, and targeted transdermal delivery. It alters the surface tension and viscosity of permeating substances, facilitates transdermal drug penetration, and utilizes nanoscale properties for precise, targeted delivery. Remarkably, ILs-SAMs were compared with other ILs self-assembled nanoparticles (ILs-SANPs) and polymer micelles, and the former possessed superior properties, including easier self-assembly and higher stability. Lastly, it focuses on their applications in treating skin cancer, arthritis, diabetes, fungal infections, and skin photoaging. Collectively, the novel ILs-SAMs are multifunctional transdermal drug delivery systems used for permeation enhancement, targeted drug delivery and different skin disorders.http://www.sciencedirect.com/science/article/pii/S2590156725000350Ionic liquids Self-assembled MicellesTransdermal Drug deliveryDrug delivery SystemAssembly mechanismsPermeation enhancementSkin disorders |
| spellingShingle | Ziqing Deng Shuwei Tang Mingjie Ou Zhuxian Wang Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications International Journal of Pharmaceutics: X Ionic liquids Self-assembled Micelles Transdermal Drug delivery Drug delivery System Assembly mechanisms Permeation enhancement Skin disorders |
| title | Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications |
| title_full | Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications |
| title_fullStr | Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications |
| title_full_unstemmed | Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications |
| title_short | Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications |
| title_sort | ionic liquids self assembled micelles for transdermal delivery characterization functions and applications |
| topic | Ionic liquids Self-assembled Micelles Transdermal Drug delivery Drug delivery System Assembly mechanisms Permeation enhancement Skin disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2590156725000350 |
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