Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism
Aim. To study of the relationship between gene polymorphisms (FGA, ITGA2, PAI1) and pulmonary embolism (PE).Material and methods. We examined 120 patients with pulmonary embolism, who made up the main group (mean age, 63,22±3,16 years). There were 66 men (mean age, 60,24±3,17 years) and 54 women (me...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2023-11-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5507 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249989723684864 |
|---|---|
| author | N. M. Kryuchkova S. Yu. Nikulina A. A. Chernova V. N. Maksimov |
| author_facet | N. M. Kryuchkova S. Yu. Nikulina A. A. Chernova V. N. Maksimov |
| author_sort | N. M. Kryuchkova |
| collection | DOAJ |
| description | Aim. To study of the relationship between gene polymorphisms (FGA, ITGA2, PAI1) and pulmonary embolism (PE).Material and methods. We examined 120 patients with pulmonary embolism, who made up the main group (mean age, 63,22±3,16 years). There were 66 men (mean age, 60,24±3,17 years) and 54 women (mean age, 6,19±3,67 years). The control group consisted of 200 people (mean age, 64,92±3,50 years). The DNA Bank of the Research Institute of Internal and Preventive Medicine was formed during a series of population screenings. All patients signed written informed consent to participate in the molecular genetic study. The work involved the calculation of the following output data: standard deviation; mean square; Pearson chi-squared test; likelihood ratio; Fisher's exact test and linear relationship.Results. The probability of PE among women carriers of ID genotype of FGA gene rs35496957 polymorphism in the group with PE is 2,08 times higher than that in the control group (95% confidence interval (CI), 1,06-4,09; p=0,32); among women carriers of the TT genotype of ITGA2 gene rs1126643 polymorphism in the group with PE — 3,08 times compared to the control group (95% CI, 1,36-6,97; p=0,006).Conclusion. The study of genetic factors in the development of pulmonary embolism (FGA, ITGA2, PAI-1) is necessary to create a personalized approach to patient management at all stages. |
| format | Article |
| id | doaj-art-948a54babd474a25b20ddce2ed9e4f11 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-948a54babd474a25b20ddce2ed9e4f112025-08-20T03:57:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-11-01281010.15829/1560-4071-2023-55073860Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolismN. M. Kryuchkova0S. Yu. Nikulina1A. A. Chernova2V. N. Maksimov3V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical HospitalV. F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityV. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical CenterResearch Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and GeneticsAim. To study of the relationship between gene polymorphisms (FGA, ITGA2, PAI1) and pulmonary embolism (PE).Material and methods. We examined 120 patients with pulmonary embolism, who made up the main group (mean age, 63,22±3,16 years). There were 66 men (mean age, 60,24±3,17 years) and 54 women (mean age, 6,19±3,67 years). The control group consisted of 200 people (mean age, 64,92±3,50 years). The DNA Bank of the Research Institute of Internal and Preventive Medicine was formed during a series of population screenings. All patients signed written informed consent to participate in the molecular genetic study. The work involved the calculation of the following output data: standard deviation; mean square; Pearson chi-squared test; likelihood ratio; Fisher's exact test and linear relationship.Results. The probability of PE among women carriers of ID genotype of FGA gene rs35496957 polymorphism in the group with PE is 2,08 times higher than that in the control group (95% confidence interval (CI), 1,06-4,09; p=0,32); among women carriers of the TT genotype of ITGA2 gene rs1126643 polymorphism in the group with PE — 3,08 times compared to the control group (95% CI, 1,36-6,97; p=0,006).Conclusion. The study of genetic factors in the development of pulmonary embolism (FGA, ITGA2, PAI-1) is necessary to create a personalized approach to patient management at all stages.https://russjcardiol.elpub.ru/jour/article/view/5507pulmonary embolismpolymorphismgenes |
| spellingShingle | N. M. Kryuchkova S. Yu. Nikulina A. A. Chernova V. N. Maksimov Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism Российский кардиологический журнал pulmonary embolism polymorphism genes |
| title | Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism |
| title_full | Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism |
| title_fullStr | Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism |
| title_full_unstemmed | Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism |
| title_short | Association of FGA, ITGA2, PAI-1 gene polymorphisms with pulmonary embolism |
| title_sort | association of fga itga2 pai 1 gene polymorphisms with pulmonary embolism |
| topic | pulmonary embolism polymorphism genes |
| url | https://russjcardiol.elpub.ru/jour/article/view/5507 |
| work_keys_str_mv | AT nmkryuchkova associationoffgaitga2pai1genepolymorphismswithpulmonaryembolism AT syunikulina associationoffgaitga2pai1genepolymorphismswithpulmonaryembolism AT aachernova associationoffgaitga2pai1genepolymorphismswithpulmonaryembolism AT vnmaksimov associationoffgaitga2pai1genepolymorphismswithpulmonaryembolism |