Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis
Abstract The telomerase reverse transcriptase (TERT) promoter mutations have been linked to the prognosis and survival of several cancers; however, it is still debatable in case of oral squamous cell carcinoma. The exact reason for it is currently unknown. However, considering its role in cell survi...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-98133-6 |
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| author | Monal Yuwanati Sachin Sarode Gargi Sarode Amol Gadbail Shailesh Gondivkar Akhilanand Chaurasia Dhara Dwivedi Sara Delgadillo-Barrera |
| author_facet | Monal Yuwanati Sachin Sarode Gargi Sarode Amol Gadbail Shailesh Gondivkar Akhilanand Chaurasia Dhara Dwivedi Sara Delgadillo-Barrera |
| author_sort | Monal Yuwanati |
| collection | DOAJ |
| description | Abstract The telomerase reverse transcriptase (TERT) promoter mutations have been linked to the prognosis and survival of several cancers; however, it is still debatable in case of oral squamous cell carcinoma. The exact reason for it is currently unknown. However, considering its role in cell survival and proliferation it is imperative to evaluate the association between TERT promoter mutations and OSCC. The systematic review and meta-analysis were carried out to gather evidence for TERT promotor mutation in OSCC. Electronic databases along with grey literature were searched for relevant studies. We used fixed- or random-effect models to calculate pooled proportion, estimated odds ratios or standardized mean differences, and corresponding 95% confidence intervals (CIs). We included 13 eligible studies incorporating 816 cases. The average frequency of TERT promotor mutation was 46.1% (0.46, 95% CI, 0.33, 0.60). However, TERT promoter mutations were not associated with gender, habit (smoking and betel nut), nodal involvement, metastases, and TNM stage. C228T (189/287), C250T (73/287), C228A, and other variants of TERT mutation were frequently detected TERT mutation variant in OSCC. TERT promoter mutations could be considered as biomarkers assisting in risk stratification and prognostic prediction. |
| format | Article |
| id | doaj-art-94817985b3b74eb4805cef73f5d35a5d |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-94817985b3b74eb4805cef73f5d35a5d2025-08-20T01:47:33ZengNature PortfolioScientific Reports2045-23222025-04-011511910.1038/s41598-025-98133-6Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysisMonal Yuwanati0Sachin Sarode1Gargi Sarode2Amol Gadbail3Shailesh Gondivkar4Akhilanand Chaurasia5Dhara Dwivedi6Sara Delgadillo-Barrera7Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha UniversityDr. D.Y. Patil Dental College & HospitalDr. D.Y. Patil Dental College & HospitalDepartment of Dentistry, Shree Bhausaheb Hire Government Medical College & HospitalGovernment Dental College & HospitalDepartment of Oral Medicine and Radiology, King George’s Medical UniversityDepartment of Dental Medicine, College of Medicine and Health Sciences, Hawassa UniversityGrupo de Investigación Básica y Aplicada en Odontologia - IBAPO, Facultad de Odontologia, Universidad Nacional de ColombiaAbstract The telomerase reverse transcriptase (TERT) promoter mutations have been linked to the prognosis and survival of several cancers; however, it is still debatable in case of oral squamous cell carcinoma. The exact reason for it is currently unknown. However, considering its role in cell survival and proliferation it is imperative to evaluate the association between TERT promoter mutations and OSCC. The systematic review and meta-analysis were carried out to gather evidence for TERT promotor mutation in OSCC. Electronic databases along with grey literature were searched for relevant studies. We used fixed- or random-effect models to calculate pooled proportion, estimated odds ratios or standardized mean differences, and corresponding 95% confidence intervals (CIs). We included 13 eligible studies incorporating 816 cases. The average frequency of TERT promotor mutation was 46.1% (0.46, 95% CI, 0.33, 0.60). However, TERT promoter mutations were not associated with gender, habit (smoking and betel nut), nodal involvement, metastases, and TNM stage. C228T (189/287), C250T (73/287), C228A, and other variants of TERT mutation were frequently detected TERT mutation variant in OSCC. TERT promoter mutations could be considered as biomarkers assisting in risk stratification and prognostic prediction.https://doi.org/10.1038/s41598-025-98133-6OSCCMutationTelomerase reverse transcriptaseC228TC250TC228A |
| spellingShingle | Monal Yuwanati Sachin Sarode Gargi Sarode Amol Gadbail Shailesh Gondivkar Akhilanand Chaurasia Dhara Dwivedi Sara Delgadillo-Barrera Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis Scientific Reports OSCC Mutation Telomerase reverse transcriptase C228T C250T C228A |
| title | Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis |
| title_full | Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis |
| title_fullStr | Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis |
| title_full_unstemmed | Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis |
| title_short | Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis |
| title_sort | association of tert promoter mutation with oral squamous cell carcinoma a systematic review and meta analysis |
| topic | OSCC Mutation Telomerase reverse transcriptase C228T C250T C228A |
| url | https://doi.org/10.1038/s41598-025-98133-6 |
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