Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro
Modifying effect of magnet driven nonocomposites containing 157Gd upon morpho-functional properties of cells was studied in the test system of L929 cell line culture. Modified with DTPA and DMSA magnet driven Gadolinium containing nonocomposites were found to have better cell biocompatibility: cells...
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| Format: | Article |
| Language: | English |
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Institute for Nuclear Research, National Academy of Sciences of Ukraine
2014-06-01
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| Series: | Ядерна фізика та енергетика |
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| Online Access: | http://jnpae.kinr.kiev.ua/15.2/Articles_PDF/jnpae-2014-15-0163-Lavrenchuk.pdf |
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| author | H. I. Lavrenchuk Yu. B. Shevchenko A. L. Petranovs'ka E. V. Pylypchuk I. V. Kozlovs'ka |
| author_facet | H. I. Lavrenchuk Yu. B. Shevchenko A. L. Petranovs'ka E. V. Pylypchuk I. V. Kozlovs'ka |
| author_sort | H. I. Lavrenchuk |
| collection | DOAJ |
| description | Modifying effect of magnet driven nonocomposites containing 157Gd upon morpho-functional properties of cells was studied in the test system of L929 cell line culture. Modified with DTPA and DMSA magnet driven Gadolinium containing nonocomposites were found to have better cell biocompatibility: cells incubation with these NCA showed no toxicity in studied concentrations range, except the largest ones, at the same time decreas-ing adhesive properties of the cells. Decrease of mitotic activity along with preservation of control cell popula-tion density suggests synchronization of cell division was observed. Oleate sodium stabilized ferrite was found to cause destructive changes in the cell culture only at the concentration of 500 μg/ml, however it decreased mitotic activity in the cell culture by 3 to 5 times in the whole concentrations range. Magnet driven nanocomposites were shown to induct apoptosis in cell culture the
extent of which depended upon agent concentration. |
| format | Article |
| id | doaj-art-947d62de67ae4a228cd252f479b4a75d |
| institution | OA Journals |
| issn | 1818-331X 2074-0565 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Institute for Nuclear Research, National Academy of Sciences of Ukraine |
| record_format | Article |
| series | Ядерна фізика та енергетика |
| spelling | doaj-art-947d62de67ae4a228cd252f479b4a75d2025-08-20T01:58:12ZengInstitute for Nuclear Research, National Academy of Sciences of UkraineЯдерна фізика та енергетика1818-331X2074-05652014-06-01152163170Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitroH. I. Lavrenchuk0Yu. B. Shevchenko1A. L. Petranovs'ka2E. V. Pylypchuk3I. V. Kozlovs'ka4SI "National Research Center for Radiation Medicine NAMS of Ukraine", Kyiv, UkraineInstitute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, UkarineO. O. Chuyko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineO. O. Chuyko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineSI "National Research Center for Radiation Medicine NAMS of Ukraine", Kyiv, UkraineModifying effect of magnet driven nonocomposites containing 157Gd upon morpho-functional properties of cells was studied in the test system of L929 cell line culture. Modified with DTPA and DMSA magnet driven Gadolinium containing nonocomposites were found to have better cell biocompatibility: cells incubation with these NCA showed no toxicity in studied concentrations range, except the largest ones, at the same time decreas-ing adhesive properties of the cells. Decrease of mitotic activity along with preservation of control cell popula-tion density suggests synchronization of cell division was observed. Oleate sodium stabilized ferrite was found to cause destructive changes in the cell culture only at the concentration of 500 μg/ml, however it decreased mitotic activity in the cell culture by 3 to 5 times in the whole concentrations range. Magnet driven nanocomposites were shown to induct apoptosis in cell culture the extent of which depended upon agent concentration.http://jnpae.kinr.kiev.ua/15.2/Articles_PDF/jnpae-2014-15-0163-Lavrenchuk.pdfneutron capture therapymagnet driven nanocompositesproliferationapoptosis |
| spellingShingle | H. I. Lavrenchuk Yu. B. Shevchenko A. L. Petranovs'ka E. V. Pylypchuk I. V. Kozlovs'ka Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro Ядерна фізика та енергетика neutron capture therapy magnet driven nanocomposites proliferation apoptosis |
| title | Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| title_full | Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| title_fullStr | Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| title_full_unstemmed | Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| title_short | Impact of 157Gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| title_sort | impact of 157gd containing nanoscale magnetosensitive composites on morfofunctional properties of cells in vitro |
| topic | neutron capture therapy magnet driven nanocomposites proliferation apoptosis |
| url | http://jnpae.kinr.kiev.ua/15.2/Articles_PDF/jnpae-2014-15-0163-Lavrenchuk.pdf |
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