Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model

Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model

Background Adoptive cell therapy using genetically modified T cells to express chimeric antigen receptors (CAR-T) has shown encouraging results, particularly in certain blood cancers. Nevertheless, over 40% of B cell malignancy patients experience a relapse after CAR-T therapy, likely due to inadequ...

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Main Authors: Felipe Prosper, Sandra Hervás-Stubbs, Juan Jose Lasarte, Noelia Casares, Teresa Lozano, Celia Martín-Otal, Aritz Lasarte-Cia, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, Juan Roberto Rodriguez-Madoz, Jesús San Miguel, Lorea Jordana
Format: Article
Language:English
Published: BMJ Publishing Group 2024-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/7/e008572.full
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