Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation
Abstract New possibilities offered by Magnetic Particle Spectroscopy (MPS) and Imaging (MPI) are increasingly being recognized and may accelerate the introduction of MPI into clinical settings. As MPI is a tracer‐based imaging method, the design and development of responsive tracers for functional i...
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Wiley-VCH
2025-06-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202400189 |
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| author | Fabian H. L. Starsich Julia Feye Robert Niβler Gabriela Da Silva André Elena Totter Konrad Scheffler Florian Thieben Erik Mayr Jochen Franke Tobias Knopp Inge K. Herrmann |
| author_facet | Fabian H. L. Starsich Julia Feye Robert Niβler Gabriela Da Silva André Elena Totter Konrad Scheffler Florian Thieben Erik Mayr Jochen Franke Tobias Knopp Inge K. Herrmann |
| author_sort | Fabian H. L. Starsich |
| collection | DOAJ |
| description | Abstract New possibilities offered by Magnetic Particle Spectroscopy (MPS) and Imaging (MPI) are increasingly being recognized and may accelerate the introduction of MPI into clinical settings. As MPI is a tracer‐based imaging method, the design and development of responsive tracers for functional imaging are particularly appealing. Here, Mn‐ferrite (MnxFe3‐xO4) nanoparticles with finely tuned magnetic properties and enzyme‐like capabilities are reported as potential multifunctional theranostic agents. By adjusting the Mn content in the iron oxide matrix, the magnetic particle imaging signal of different tracers can be tweaked, allowing for the simultaneous quantitative detection of two different tracers in a multi‐color approach. The Mn2FeO4 tracers exhibit potent enzyme‐like catalytic properties, enabling degradation of reactive oxygen species, including H2O2 and OH−. Due to the readily interchangeable oxidation states of Mn and Fe atoms in the crystal structure, a strong dependence of the magnetic properties is observed on H2O2 exposure, which can be exploited for sensing. This enables, for the first time, the sensing of reactive oxygen species based on magnetic particle spectroscopy and imaging, with sensitivity down to 25 µm H2O2 and complete sensor recovery over time. In summary, Mn‐ferrite nanoparticles hold promising potential for imaging, sensing, and degradation of disease‐relevant reactive oxygen species. |
| format | Article |
| id | doaj-art-947129a02ea548e5b4ab9736610f046b |
| institution | Kabale University |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-947129a02ea548e5b4ab9736610f046b2025-08-20T03:25:39ZengWiley-VCHAdvanced Sensor Research2751-12192025-06-0146n/an/a10.1002/adsr.202400189Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species DegradationFabian H. L. Starsich0Julia Feye1Robert Niβler2Gabriela Da Silva André3Elena Totter4Konrad Scheffler5Florian Thieben6Erik Mayr7Jochen Franke8Tobias Knopp9Inge K. Herrmann10Nanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandSection for Biomedical Imaging University Medical Center Hamburg‐Eppendorf Lottestraße 55 22529 Hamburg GermanySection for Biomedical Imaging University Medical Center Hamburg‐Eppendorf Lottestraße 55 22529 Hamburg GermanyNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandBruker BioSpin GmbH Co. KG Preclinical Imaging Division 76275 Ettlingen GermanySection for Biomedical Imaging University Medical Center Hamburg‐Eppendorf Lottestraße 55 22529 Hamburg GermanyNanoparticle Systems Engineering Laboratory Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 SwitzerlandAbstract New possibilities offered by Magnetic Particle Spectroscopy (MPS) and Imaging (MPI) are increasingly being recognized and may accelerate the introduction of MPI into clinical settings. As MPI is a tracer‐based imaging method, the design and development of responsive tracers for functional imaging are particularly appealing. Here, Mn‐ferrite (MnxFe3‐xO4) nanoparticles with finely tuned magnetic properties and enzyme‐like capabilities are reported as potential multifunctional theranostic agents. By adjusting the Mn content in the iron oxide matrix, the magnetic particle imaging signal of different tracers can be tweaked, allowing for the simultaneous quantitative detection of two different tracers in a multi‐color approach. The Mn2FeO4 tracers exhibit potent enzyme‐like catalytic properties, enabling degradation of reactive oxygen species, including H2O2 and OH−. Due to the readily interchangeable oxidation states of Mn and Fe atoms in the crystal structure, a strong dependence of the magnetic properties is observed on H2O2 exposure, which can be exploited for sensing. This enables, for the first time, the sensing of reactive oxygen species based on magnetic particle spectroscopy and imaging, with sensitivity down to 25 µm H2O2 and complete sensor recovery over time. In summary, Mn‐ferrite nanoparticles hold promising potential for imaging, sensing, and degradation of disease‐relevant reactive oxygen species.https://doi.org/10.1002/adsr.202400189magnetic particle spectroscopynanozymesensortheranosticstissue injury |
| spellingShingle | Fabian H. L. Starsich Julia Feye Robert Niβler Gabriela Da Silva André Elena Totter Konrad Scheffler Florian Thieben Erik Mayr Jochen Franke Tobias Knopp Inge K. Herrmann Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation Advanced Sensor Research magnetic particle spectroscopy nanozyme sensor theranostics tissue injury |
| title | Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation |
| title_full | Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation |
| title_fullStr | Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation |
| title_full_unstemmed | Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation |
| title_short | Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation |
| title_sort | responsive mn ferrite nanoparticles for multicolor magnetic particle imaging sensing and reactive oxygen species degradation |
| topic | magnetic particle spectroscopy nanozyme sensor theranostics tissue injury |
| url | https://doi.org/10.1002/adsr.202400189 |
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