Effect of icatibant on sweating-induced dermal pain
BackgroundExposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/jcia.2025.14276/full |
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| author | Shunsuke Takahagi Shunsuke Takahagi Daiki Matsubara Emi Murakami Yumi Aoyama Shinya Imamura Atsushi Fukunaga Atsushi Fukunaga Yoshiko Oda Hiroyuki Murota Michihiro Hide Michihiro Hide |
| author_facet | Shunsuke Takahagi Shunsuke Takahagi Daiki Matsubara Emi Murakami Yumi Aoyama Shinya Imamura Atsushi Fukunaga Atsushi Fukunaga Yoshiko Oda Hiroyuki Murota Michihiro Hide Michihiro Hide |
| author_sort | Shunsuke Takahagi |
| collection | DOAJ |
| description | BackgroundExposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pathomechanism.MethodsThis single-blind, randomized, crossover study enrolled adult patients who had experienced severe sweating-induced dermal pain. Participants randomly received icatibant (30 mg) or placebo on Day 1 and vice versa on Day 2. Before and after drug administration, dermal pain induced by an artificial thermal loading was assessed using the visual analog scale (VAS).ResultsFour patients were enrolled, three of whom completed the full procedure with the termination in the other. Among the three patients, the pain-VAS score decreased more with icatibant than with saline in one patient, whereas it decreased more with saline than with icatibant in the other two patients. The pain duration decreased more with icatibant than with saline in two patients, whereas it decreased equally with both treatments in the other. Icatibant did not affect the changes in whole blood and plasma histamine, and serum angiotensin-converting enzyme levels after the induction of the dermal pain. A safety profile showed injection site pain associated with icatibant.ConclusionBlockade of bradykinin B2 receptor signaling by icatibant contributed to the reduction of dermal pain during sweating stimuli in one patient but not in two others. The role of bradykinin in the dermal pain varies among patients.Clinical trial registrationhttps://jrct.niph.go.jp/, identifier jRCTs061210021. |
| format | Article |
| id | doaj-art-946e12fbae95444b9345cb6815f50151 |
| institution | Kabale University |
| issn | 2574-4593 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj-art-946e12fbae95444b9345cb6815f501512025-02-10T04:11:07ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932025-02-01810.3389/jcia.2025.1427614276Effect of icatibant on sweating-induced dermal painShunsuke Takahagi0Shunsuke Takahagi1Daiki Matsubara2Emi Murakami3Yumi Aoyama4Shinya Imamura5Atsushi Fukunaga6Atsushi Fukunaga7Yoshiko Oda8Hiroyuki Murota9Michihiro Hide10Michihiro Hide11Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Dermatology, JA Hiroshima General Hospital, Hiroshima, JapanDepartment of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Dermatology, Kawasaki Medical School, Kurashiki, JapanDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Dermatology, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, JapanDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanDepartment of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Dermatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, JapanBackgroundExposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pathomechanism.MethodsThis single-blind, randomized, crossover study enrolled adult patients who had experienced severe sweating-induced dermal pain. Participants randomly received icatibant (30 mg) or placebo on Day 1 and vice versa on Day 2. Before and after drug administration, dermal pain induced by an artificial thermal loading was assessed using the visual analog scale (VAS).ResultsFour patients were enrolled, three of whom completed the full procedure with the termination in the other. Among the three patients, the pain-VAS score decreased more with icatibant than with saline in one patient, whereas it decreased more with saline than with icatibant in the other two patients. The pain duration decreased more with icatibant than with saline in two patients, whereas it decreased equally with both treatments in the other. Icatibant did not affect the changes in whole blood and plasma histamine, and serum angiotensin-converting enzyme levels after the induction of the dermal pain. A safety profile showed injection site pain associated with icatibant.ConclusionBlockade of bradykinin B2 receptor signaling by icatibant contributed to the reduction of dermal pain during sweating stimuli in one patient but not in two others. The role of bradykinin in the dermal pain varies among patients.Clinical trial registrationhttps://jrct.niph.go.jp/, identifier jRCTs061210021.https://www.frontierspartnerships.org/articles/10.3389/jcia.2025.14276/fulldermal painsweatingicatibantbradykininhistamine |
| spellingShingle | Shunsuke Takahagi Shunsuke Takahagi Daiki Matsubara Emi Murakami Yumi Aoyama Shinya Imamura Atsushi Fukunaga Atsushi Fukunaga Yoshiko Oda Hiroyuki Murota Michihiro Hide Michihiro Hide Effect of icatibant on sweating-induced dermal pain Journal of Cutaneous Immunology and Allergy dermal pain sweating icatibant bradykinin histamine |
| title | Effect of icatibant on sweating-induced dermal pain |
| title_full | Effect of icatibant on sweating-induced dermal pain |
| title_fullStr | Effect of icatibant on sweating-induced dermal pain |
| title_full_unstemmed | Effect of icatibant on sweating-induced dermal pain |
| title_short | Effect of icatibant on sweating-induced dermal pain |
| title_sort | effect of icatibant on sweating induced dermal pain |
| topic | dermal pain sweating icatibant bradykinin histamine |
| url | https://www.frontierspartnerships.org/articles/10.3389/jcia.2025.14276/full |
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