Progress of Research on Transformation of Chronic Pancreatitis to Cancer
The transformation from inflammation to cancer is a complex pathological process, in which the inflammatory state progresses to the formation of malignant tumors. Chronic pancreatitis (CP) is a progressively inflammatory and fibrosing disease, predominantly featuring acinar cell atrophy owing to the...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2024-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0475 |
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| author | Bangwei HUANG Pengyuan WANG Lianghao HU Zhaoshen LI |
| author_facet | Bangwei HUANG Pengyuan WANG Lianghao HU Zhaoshen LI |
| author_sort | Bangwei HUANG |
| collection | DOAJ |
| description | The transformation from inflammation to cancer is a complex pathological process, in which the inflammatory state progresses to the formation of malignant tumors. Chronic pancreatitis (CP) is a progressively inflammatory and fibrosing disease, predominantly featuring acinar cell atrophy owing to the cellular damage and fibrosis of the pancreatic parenchyma. This review centers on elucidating how prolonged exposure to a chronic inflammatory environment prompts adaptive changes in acinar cells, which may ultimately lead to their conversion into cancerous cells. By delving into the pivotal role of acinar-to-ductal metaplasia, this article investigates the multi-stage pathway of CP progression into pancreatic cancer, as well as the underlying molecular regulatory networks. We aim to light on the profound mechanisms of CP's inflammation-driven carcinogenic transformation, and thus provide a scientific foundation for devising innovative preventive strategies and therapeutic interventions targeted at mitigating or halting this lethal conversion process. |
| format | Article |
| id | doaj-art-9469ffdbd55c4bc2a0e9e5ede9252eb1 |
| institution | DOAJ |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-9469ffdbd55c4bc2a0e9e5ede9252eb12025-08-20T02:52:12ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-12-01511298999310.3971/j.issn.1000-8578.2024.24.047520240475Progress of Research on Transformation of Chronic Pancreatitis to CancerBangwei HUANG0Pengyuan WANG1Lianghao HU2Zhaoshen LI3Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, ChinaThe transformation from inflammation to cancer is a complex pathological process, in which the inflammatory state progresses to the formation of malignant tumors. Chronic pancreatitis (CP) is a progressively inflammatory and fibrosing disease, predominantly featuring acinar cell atrophy owing to the cellular damage and fibrosis of the pancreatic parenchyma. This review centers on elucidating how prolonged exposure to a chronic inflammatory environment prompts adaptive changes in acinar cells, which may ultimately lead to their conversion into cancerous cells. By delving into the pivotal role of acinar-to-ductal metaplasia, this article investigates the multi-stage pathway of CP progression into pancreatic cancer, as well as the underlying molecular regulatory networks. We aim to light on the profound mechanisms of CP's inflammation-driven carcinogenic transformation, and thus provide a scientific foundation for devising innovative preventive strategies and therapeutic interventions targeted at mitigating or halting this lethal conversion process.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0475chronic pancreatitisinflammation-cancer transitionpancreatic canceracinar-to-ductal metaplasiapancreatic fibrosis |
| spellingShingle | Bangwei HUANG Pengyuan WANG Lianghao HU Zhaoshen LI Progress of Research on Transformation of Chronic Pancreatitis to Cancer Zhongliu Fangzhi Yanjiu chronic pancreatitis inflammation-cancer transition pancreatic cancer acinar-to-ductal metaplasia pancreatic fibrosis |
| title | Progress of Research on Transformation of Chronic Pancreatitis to Cancer |
| title_full | Progress of Research on Transformation of Chronic Pancreatitis to Cancer |
| title_fullStr | Progress of Research on Transformation of Chronic Pancreatitis to Cancer |
| title_full_unstemmed | Progress of Research on Transformation of Chronic Pancreatitis to Cancer |
| title_short | Progress of Research on Transformation of Chronic Pancreatitis to Cancer |
| title_sort | progress of research on transformation of chronic pancreatitis to cancer |
| topic | chronic pancreatitis inflammation-cancer transition pancreatic cancer acinar-to-ductal metaplasia pancreatic fibrosis |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0475 |
| work_keys_str_mv | AT bangweihuang progressofresearchontransformationofchronicpancreatitistocancer AT pengyuanwang progressofresearchontransformationofchronicpancreatitistocancer AT lianghaohu progressofresearchontransformationofchronicpancreatitistocancer AT zhaoshenli progressofresearchontransformationofchronicpancreatitistocancer |