Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms
BackgroundInflammatory bowel disease (IBD) has been reported to be associated with risk of uterine cervical neoplasm. We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis.MethodsWe derived instrumental variables...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1436512/full |
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| author | Chunge Cao Xiaorui Sun Xiaohu Chen Ying Zhang Chaoyan Yue |
| author_facet | Chunge Cao Xiaorui Sun Xiaohu Chen Ying Zhang Chaoyan Yue |
| author_sort | Chunge Cao |
| collection | DOAJ |
| description | BackgroundInflammatory bowel disease (IBD) has been reported to be associated with risk of uterine cervical neoplasm. We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis.MethodsWe derived instrumental variables for IBD, including Crohn’s disease and ulcerative colitis, from the IEU Open genome-wide association study (GWAS) database, and for the histological subtypes of uterine cervical neoplasm from the FinnGen repository’s GWAS data. The collected GWAS data predominantly represent individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as primary analysis approach.ResultsIBD (IVW odds ratio = 1.127, 95% confidence interval = 1.016–1.251; p = 0.024) and CD (IVW odds ratio = 1.119, 95% confidence interval = 1.023–1.224; p = 0.014) exhibited a significant causal effect on malignant cervical carcinoma. Sensitivity analyses confirmed these findings.ConclusionGenetically predicted IBD and CD are risk factors for the development of malignant cervical carcinoma. Patients with IBD and CD require specific attention to prevent cervical squamous cell carcinoma. Further studies to elucidate the underlying mechanisms may reveal new therapeutic targets. |
| format | Article |
| id | doaj-art-9464e3c7eb9743d4a73517d9be166798 |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj-art-9464e3c7eb9743d4a73517d9be1667982025-01-28T06:41:16ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-01-011510.3389/fgene.2024.14365121436512Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasmsChunge Cao0Xiaorui Sun1Xiaohu Chen2Ying Zhang3Chaoyan Yue4Department of Obstetrics and Gynecology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaShanghai YK Pao School, Shanghai, ChinaObstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaObstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaObstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaBackgroundInflammatory bowel disease (IBD) has been reported to be associated with risk of uterine cervical neoplasm. We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis.MethodsWe derived instrumental variables for IBD, including Crohn’s disease and ulcerative colitis, from the IEU Open genome-wide association study (GWAS) database, and for the histological subtypes of uterine cervical neoplasm from the FinnGen repository’s GWAS data. The collected GWAS data predominantly represent individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as primary analysis approach.ResultsIBD (IVW odds ratio = 1.127, 95% confidence interval = 1.016–1.251; p = 0.024) and CD (IVW odds ratio = 1.119, 95% confidence interval = 1.023–1.224; p = 0.014) exhibited a significant causal effect on malignant cervical carcinoma. Sensitivity analyses confirmed these findings.ConclusionGenetically predicted IBD and CD are risk factors for the development of malignant cervical carcinoma. Patients with IBD and CD require specific attention to prevent cervical squamous cell carcinoma. Further studies to elucidate the underlying mechanisms may reveal new therapeutic targets.https://www.frontiersin.org/articles/10.3389/fgene.2024.1436512/fullinflammatory bowel diseaseCrohn’s diseaseulcerative colitisuterine cervical neoplasmMendelian randomization |
| spellingShingle | Chunge Cao Xiaorui Sun Xiaohu Chen Ying Zhang Chaoyan Yue Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms Frontiers in Genetics inflammatory bowel disease Crohn’s disease ulcerative colitis uterine cervical neoplasm Mendelian randomization |
| title | Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| title_full | Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| title_fullStr | Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| title_full_unstemmed | Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| title_short | Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| title_sort | mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis uterine cervical neoplasm Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1436512/full |
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