Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart

Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart

<b>Background/Objectives:</b> Modified messenger RNA (modRNA) is a promising gene delivery method used to upregulate genes in cardiac tissue, with applications in both clinical and preclinical settings to prevent cardiac remodeling after ischemic injury. The 5′ untranslated region (5′UTR...

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Main Authors: Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
modified RNA (modRNA)
5′ untranslated region
cardiac gene therapy
translation efficiency
synthetic RNA motif
Online Access:https://www.mdpi.com/1999-4923/17/4/490
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