Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT.
<h4>Background</h4>Despite the HPV vaccine's effectiveness against cervical cancer, uptake among adolescent girls in China remains low, with caregivers playing a crucial role in vaccination decisions. This study investigates factors influencing caregivers' action to vaccinate t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0324260 |
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| author | Ying Yang Yajiao Lu Yifan Li Chuanyu Qin Yu He Wenfeng Gong Shenglan Tang Dan Wu Jing Li |
| author_facet | Ying Yang Yajiao Lu Yifan Li Chuanyu Qin Yu He Wenfeng Gong Shenglan Tang Dan Wu Jing Li |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | <h4>Background</h4>Despite the HPV vaccine's effectiveness against cervical cancer, uptake among adolescent girls in China remains low, with caregivers playing a crucial role in vaccination decisions. This study investigates factors influencing caregivers' action to vaccinate their adolescent daughters.<h4>Methods</h4>Pay-it-forward is a novel model that motivates participants in adopting healthy behaviors and making community contributions. In this study, it offers an individual a free shot of HPV vaccine and then asks whether they would like to donate to support another person to get the same vaccination. This study was embedded in a two-arm randomized controlled trial in China. Potential associated factors were identified based on Anderson's Health Service Utilization Behavioral Model and analyzed through univariate and multivariate binary logistic regression. Caregivers' information, knowledge, attitudes, vaccine confidence, hesitancy, and willingness to vaccinate were collected through online questionnaires. The endpoint was the receipt of the first dose HPV vaccine following an intervention or no intervention (pay-it-forward vs. standard-of-care), which was obtained from an electronic vaccination registry system.<h4>Results</h4>Among 321 caregivers, 25.9% of their daughters received the HPV vaccine, with 34.2% in the pay-it-forward group and 17.5% in the standard-of-care group. Daughters of caregivers who were previously unaware of the HPV vaccine were three times more likely to be vaccinated (OR=3.01,95%CI:1.27-7.14). Caregivers who did not intend to delay vaccination had daughters with eight times higher vaccination uptake (OR=8.26,95%CI:4.36-15.67). Participation in the "pay-it-forward" intervention increased vaccination rates by more than twofold (OR=2.22,95%CI:1.19-4.15). Daughters of unemployed or retired caregivers had nearly four times higher vaccination rates compared to those whose caregivers were employed (OR=3.97,95%CI:1.81-8.72). Prior refusal of the vaccine by caregivers was associated with an 80% reduction in vaccination uptake among daughters (OR=0.23,95%CI:0.06-0.81).<h4>Conclusion</h4>The pay-it-forward intervention, caregivers' knowledge, intention to delay vaccination, occupation, and prior vaccine refusal significantly influence HPV vaccine uptake among adolescent girls in China. Tailored health education, financial support, and community involvement are essential to encourage HPV vaccination among adolescent girls in China. |
| format | Article |
| id | doaj-art-9460706905084b5d90d56edd32bea4e8 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-9460706905084b5d90d56edd32bea4e82025-08-20T02:10:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032426010.1371/journal.pone.0324260Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT.Ying YangYajiao LuYifan LiChuanyu QinYu HeWenfeng GongShenglan TangDan WuJing Li<h4>Background</h4>Despite the HPV vaccine's effectiveness against cervical cancer, uptake among adolescent girls in China remains low, with caregivers playing a crucial role in vaccination decisions. This study investigates factors influencing caregivers' action to vaccinate their adolescent daughters.<h4>Methods</h4>Pay-it-forward is a novel model that motivates participants in adopting healthy behaviors and making community contributions. In this study, it offers an individual a free shot of HPV vaccine and then asks whether they would like to donate to support another person to get the same vaccination. This study was embedded in a two-arm randomized controlled trial in China. Potential associated factors were identified based on Anderson's Health Service Utilization Behavioral Model and analyzed through univariate and multivariate binary logistic regression. Caregivers' information, knowledge, attitudes, vaccine confidence, hesitancy, and willingness to vaccinate were collected through online questionnaires. The endpoint was the receipt of the first dose HPV vaccine following an intervention or no intervention (pay-it-forward vs. standard-of-care), which was obtained from an electronic vaccination registry system.<h4>Results</h4>Among 321 caregivers, 25.9% of their daughters received the HPV vaccine, with 34.2% in the pay-it-forward group and 17.5% in the standard-of-care group. Daughters of caregivers who were previously unaware of the HPV vaccine were three times more likely to be vaccinated (OR=3.01,95%CI:1.27-7.14). Caregivers who did not intend to delay vaccination had daughters with eight times higher vaccination uptake (OR=8.26,95%CI:4.36-15.67). Participation in the "pay-it-forward" intervention increased vaccination rates by more than twofold (OR=2.22,95%CI:1.19-4.15). Daughters of unemployed or retired caregivers had nearly four times higher vaccination rates compared to those whose caregivers were employed (OR=3.97,95%CI:1.81-8.72). Prior refusal of the vaccine by caregivers was associated with an 80% reduction in vaccination uptake among daughters (OR=0.23,95%CI:0.06-0.81).<h4>Conclusion</h4>The pay-it-forward intervention, caregivers' knowledge, intention to delay vaccination, occupation, and prior vaccine refusal significantly influence HPV vaccine uptake among adolescent girls in China. Tailored health education, financial support, and community involvement are essential to encourage HPV vaccination among adolescent girls in China.https://doi.org/10.1371/journal.pone.0324260 |
| spellingShingle | Ying Yang Yajiao Lu Yifan Li Chuanyu Qin Yu He Wenfeng Gong Shenglan Tang Dan Wu Jing Li Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. PLoS ONE |
| title | Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. |
| title_full | Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. |
| title_fullStr | Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. |
| title_full_unstemmed | Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. |
| title_short | Factors affecting caregivers' HPV vaccination decisions for adolescent girls: A secondary analysis of a Chinese RCT. |
| title_sort | factors affecting caregivers hpv vaccination decisions for adolescent girls a secondary analysis of a chinese rct |
| url | https://doi.org/10.1371/journal.pone.0324260 |
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