Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications
ABSTRACT Metal‐enhanced fluorescence (MEF) represents a captivating phenomenon that transpires when fluorophores are situated in close vicinity to the surface of metallic nanostructures, leading to a nuanced augmentation of their fluorescent characteristics. Given its efficacy in enhancing excitatio...
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| Format: | Article |
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Wiley
2025-05-01
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| Online Access: | https://doi.org/10.1002/agt2.744 |
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| author | Caiping Ding Wenjing Li Xiaolin Huang Ben Zhong Tang Youju Huang |
| author_facet | Caiping Ding Wenjing Li Xiaolin Huang Ben Zhong Tang Youju Huang |
| author_sort | Caiping Ding |
| collection | DOAJ |
| description | ABSTRACT Metal‐enhanced fluorescence (MEF) represents a captivating phenomenon that transpires when fluorophores are situated in close vicinity to the surface of metallic nanostructures, leading to a nuanced augmentation of their fluorescent characteristics. Given its efficacy in enhancing excitation rates, quantum yield, and photostability, MEF has firmly established itself as a highly valuable tool for augmenting biosensor sensitivity, bioimaging clarity, and intensifying therapeutic responses. Notably, plasmonic gold nanostructures, inherently advantageous for MEF, have been widely utilized in signal amplification, fluorescent labeling, and theranostics. In this endeavor, we undertake a comprehensive examination of MEF‐enabled gold nanostructures, meticulously analyzing their fundamental enhancement mechanisms, crucial influencing factors, and diverse modes of enhancement. Furthermore, we spotlight the exemplary applications of these nanostructures in biosensing, bioimaging, and theranostics, underscoring their revolutionary potential. Ultimately, we offer a glimpse into the future prospects for improvement and the challenges that beset gold‐based MEF. Our attention is steadfastly directed toward the essential scientific questions and technical hurdles that remain to be surmounted, inviting readers to partake in an exciting exploration of this dynamic and promising field. |
| format | Article |
| id | doaj-art-945b58c310a044a894236466bc36e3d5 |
| institution | OA Journals |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-945b58c310a044a894236466bc36e3d52025-08-20T01:52:11ZengWileyAggregate2692-45602025-05-0165n/an/a10.1002/agt2.744Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical ApplicationsCaiping Ding0Wenjing Li1Xiaolin Huang2Ben Zhong Tang3Youju Huang4College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Key Laboratory of Organosilicon Material Technology Hangzhou Normal University Hangzhou Zhejiang ChinaState Key Laboratory of Food Science and Resources, School of Food Science and Technology Nanchang University Nanchang Jiangxi ChinaState Key Laboratory of Food Science and Resources, School of Food Science and Technology Nanchang University Nanchang Jiangxi ChinaSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong ChinaCollege of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Key Laboratory of Organosilicon Material Technology Hangzhou Normal University Hangzhou Zhejiang ChinaABSTRACT Metal‐enhanced fluorescence (MEF) represents a captivating phenomenon that transpires when fluorophores are situated in close vicinity to the surface of metallic nanostructures, leading to a nuanced augmentation of their fluorescent characteristics. Given its efficacy in enhancing excitation rates, quantum yield, and photostability, MEF has firmly established itself as a highly valuable tool for augmenting biosensor sensitivity, bioimaging clarity, and intensifying therapeutic responses. Notably, plasmonic gold nanostructures, inherently advantageous for MEF, have been widely utilized in signal amplification, fluorescent labeling, and theranostics. In this endeavor, we undertake a comprehensive examination of MEF‐enabled gold nanostructures, meticulously analyzing their fundamental enhancement mechanisms, crucial influencing factors, and diverse modes of enhancement. Furthermore, we spotlight the exemplary applications of these nanostructures in biosensing, bioimaging, and theranostics, underscoring their revolutionary potential. Ultimately, we offer a glimpse into the future prospects for improvement and the challenges that beset gold‐based MEF. Our attention is steadfastly directed toward the essential scientific questions and technical hurdles that remain to be surmounted, inviting readers to partake in an exciting exploration of this dynamic and promising field.https://doi.org/10.1002/agt2.744biomedical applicationsmetal‐enhanced fluorescencemultifunctional nanoprobeplasmonic gold nanoparticle |
| spellingShingle | Caiping Ding Wenjing Li Xiaolin Huang Ben Zhong Tang Youju Huang Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications Aggregate biomedical applications metal‐enhanced fluorescence multifunctional nanoprobe plasmonic gold nanoparticle |
| title | Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications |
| title_full | Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications |
| title_fullStr | Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications |
| title_full_unstemmed | Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications |
| title_short | Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications |
| title_sort | multifunctional ultra bright plasmonic gold fluorescence nanoprobe for biomedical applications |
| topic | biomedical applications metal‐enhanced fluorescence multifunctional nanoprobe plasmonic gold nanoparticle |
| url | https://doi.org/10.1002/agt2.744 |
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