HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts

HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts

Abstract Living liver transplantation has become a significant and evolving aspect of organ transplantation, with a notable proportion of cases involving pediatric patients. Metabolic-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease. The growing number of individual...

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Bibliographic Details
Main Authors: Tao Li, Pengkang Chang, Yimeng Wang, Yihong Song, Pengxiang Qu, Bo Wang, Yi Lyu, Liangshuo Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Hypothermic oxygenated perfusion (HOPE)
Steatotic liver grafts
Living liver transplantation
AMPK activator
Primate models
Online Access:https://doi.org/10.1038/s41598-025-96265-3
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