The first case of papillary thyroid carcinoma in an adolescent with congenital dyshormonogenetic hypothyroidism in Serbia
Introduction. Differentiated thyroid carcinoma (DTC) is a rare childhood malignancy, as it represents 0.3-0.4% of pediatric malignancies. Papillary carcinoma is the most common type of pediatric DTC and it represents about 90% of all DTC patients. Although rare, DTC arising from dyshormonog...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501411078E.pdf |
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| Summary: | Introduction. Differentiated thyroid carcinoma (DTC) is a rare childhood
malignancy, as it represents 0.3-0.4% of pediatric malignancies. Papillary
carcinoma is the most common type of pediatric DTC and it represents about
90% of all DTC patients. Although rare, DTC arising from dyshormonogenetic
goiter is the most serious complication of congenital hypothyroidism. Case
report. We presented the development of thyroid papillary carcinoma in a
15-year-old girl diagnosed with congenital dyshormonogenetic hypothyroidism
at neonatal age. Considering the early initiation and proper dosage of
hormonal substitution, normal levels of thyreotropin and thyroid hormones
were achieved quickly and maintained through a follow-up period. The girl
remained euthyroid and asymptomatic until 13.8 years of age, when she
presented with a large multinodular goiter. The patient underwent total
thyroidectomy. Pathological examination revealed intrathyroid microcarcinoma
in the right lobe. Conclusion. Although differentiated thyroid carcinoma is a
rare pediatric malignancy, it is of great importance to have a certain degree
of clinical caution and provide a multidisciplinary approach during the
follow-up of patients with dyshormonogenetic hypothyroidism. |
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| ISSN: | 0042-8450 |