The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis
Osteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which lead...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2012/706905 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548338753339392 |
|---|---|
| author | M. E. Nadia A. S. Nazrun M. Norazlina N. M. Isa M. Norliza S. Ima Nirwana |
| author_facet | M. E. Nadia A. S. Nazrun M. Norazlina N. M. Isa M. Norliza S. Ima Nirwana |
| author_sort | M. E. Nadia |
| collection | DOAJ |
| description | Osteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone-formation and increase in bone-resorption activity. Estrogen is able to suppress production of proinflammatory cytokines such as IL-1, IL-6, IL-7, and TNF-α. This is why these cytokines are elevated in postmenopausal women. Studies have shown that estrogen reduction is able to stimulate focal inflammation in bone. Labisia pumila (LP) which is known to exert phytoestrogenic effect can be used as an alternative to ERT which can produce positive effects on bone without causing side effects. LP contains antioxidant as well as exerting anti-inflammatory effect which can act as free radical scavenger, thus inhibiting TNF-α production and COX-2 expression which leads to decline in RANKL expression, resulting in reduction in osteoclast activity which consequently reduces bone loss. Hence, it is the phytoestrogenic, anti-inflammatory, and antioxidative properties that make LP an effective agent against osteoporosis. |
| format | Article |
| id | doaj-art-9456cafa6e524006ba700b799740cff4 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-9456cafa6e524006ba700b799740cff42025-02-03T06:14:17ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422012-01-01201210.1155/2012/706905706905The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal OsteoporosisM. E. Nadia0A. S. Nazrun1M. Norazlina2N. M. Isa3M. Norliza4S. Ima Nirwana5Department of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur campus, 50300 Kuala Lumpur, MalaysiaOsteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone-formation and increase in bone-resorption activity. Estrogen is able to suppress production of proinflammatory cytokines such as IL-1, IL-6, IL-7, and TNF-α. This is why these cytokines are elevated in postmenopausal women. Studies have shown that estrogen reduction is able to stimulate focal inflammation in bone. Labisia pumila (LP) which is known to exert phytoestrogenic effect can be used as an alternative to ERT which can produce positive effects on bone without causing side effects. LP contains antioxidant as well as exerting anti-inflammatory effect which can act as free radical scavenger, thus inhibiting TNF-α production and COX-2 expression which leads to decline in RANKL expression, resulting in reduction in osteoclast activity which consequently reduces bone loss. Hence, it is the phytoestrogenic, anti-inflammatory, and antioxidative properties that make LP an effective agent against osteoporosis.http://dx.doi.org/10.1155/2012/706905 |
| spellingShingle | M. E. Nadia A. S. Nazrun M. Norazlina N. M. Isa M. Norliza S. Ima Nirwana The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis Advances in Pharmacological Sciences |
| title | The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis |
| title_full | The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis |
| title_fullStr | The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis |
| title_full_unstemmed | The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis |
| title_short | The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis |
| title_sort | anti inflammatory phytoestrogenic and antioxidative role of labisia pumila in prevention of postmenopausal osteoporosis |
| url | http://dx.doi.org/10.1155/2012/706905 |
| work_keys_str_mv | AT menadia theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT asnazrun theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT mnorazlina theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT nmisa theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT mnorliza theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT simanirwana theantiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT menadia antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT asnazrun antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT mnorazlina antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT nmisa antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT mnorliza antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis AT simanirwana antiinflammatoryphytoestrogenicandantioxidativeroleoflabisiapumilainpreventionofpostmenopausalosteoporosis |