Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity
Ultraviolet (UV) irradiation causes skin wrinkles and decreases elasticity. UV also increases binding between advanced glycation end products (AGEs) and the receptor for AGEs (RAGE), resulting in increased inflammation and activation of NF-κB. We evaluated whether fermented fish collagen (FC) could...
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MDPI AG
2024-12-01
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| author | Seyeon Oh So Young Lee Jong-Won Jang Kuk Hui Son Kyunghee Byun |
| author_facet | Seyeon Oh So Young Lee Jong-Won Jang Kuk Hui Son Kyunghee Byun |
| author_sort | Seyeon Oh |
| collection | DOAJ |
| description | Ultraviolet (UV) irradiation causes skin wrinkles and decreases elasticity. UV also increases binding between advanced glycation end products (AGEs) and the receptor for AGEs (RAGE), resulting in increased inflammation and activation of NF-κB. We evaluated whether fermented fish collagen (FC) could decrease photoaging via decreasing AGE–RAGE binding activity, which was associated with decreased TNF-α and NF-κB levels in UV-irradiated keratinocytes and animal skin. In the UV-irradiated keratinocytes, AGE–RAGE binding activity and TNF-α secretion levels were increased, and FC decreased these. Additionally, AGE–RAGE binding activity and TNF-α secretion levels were attenuated by soluble RAGE (RAGE inhibitor) in the UV-irradiated keratinocytes. FC decreased AGE–RAGE binding activity, TNF-α levels, and translocation of NF-κB in the UV-irradiated skin. Furthermore, FC decreased the expression of matrix metalloproteinases 1/3/9, which degrades collagen fibers, and Smad7, which inhibits Smad2/3, in UV-irradiated skin. FC increased Smad2/3 and collagen fiber accumulation. FC also increases skin moisture and elasticity. In conclusion, FC could attenuate skin photoaging via decreasing AGE–RAGE binding activity and its downstream signals such as TNF-α and NF-κB. |
| format | Article |
| id | doaj-art-9451dab2f42d4bbc8542f525d659502b |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-9451dab2f42d4bbc8542f525d659502b2025-08-20T02:55:36ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-014612143511436510.3390/cimb46120860Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding ActivitySeyeon Oh0So Young Lee1Jong-Won Jang2Kuk Hui Son3Kyunghee Byun4Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of KoreaFunctional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of KoreaDepartment of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of KoreaFunctional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of KoreaUltraviolet (UV) irradiation causes skin wrinkles and decreases elasticity. UV also increases binding between advanced glycation end products (AGEs) and the receptor for AGEs (RAGE), resulting in increased inflammation and activation of NF-κB. We evaluated whether fermented fish collagen (FC) could decrease photoaging via decreasing AGE–RAGE binding activity, which was associated with decreased TNF-α and NF-κB levels in UV-irradiated keratinocytes and animal skin. In the UV-irradiated keratinocytes, AGE–RAGE binding activity and TNF-α secretion levels were increased, and FC decreased these. Additionally, AGE–RAGE binding activity and TNF-α secretion levels were attenuated by soluble RAGE (RAGE inhibitor) in the UV-irradiated keratinocytes. FC decreased AGE–RAGE binding activity, TNF-α levels, and translocation of NF-κB in the UV-irradiated skin. Furthermore, FC decreased the expression of matrix metalloproteinases 1/3/9, which degrades collagen fibers, and Smad7, which inhibits Smad2/3, in UV-irradiated skin. FC increased Smad2/3 and collagen fiber accumulation. FC also increases skin moisture and elasticity. In conclusion, FC could attenuate skin photoaging via decreasing AGE–RAGE binding activity and its downstream signals such as TNF-α and NF-κB.https://www.mdpi.com/1467-3045/46/12/860advanced glycation end productsAGE–RAGE binding activityfermented fish collagen |
| spellingShingle | Seyeon Oh So Young Lee Jong-Won Jang Kuk Hui Son Kyunghee Byun Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity Current Issues in Molecular Biology advanced glycation end products AGE–RAGE binding activity fermented fish collagen |
| title | Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity |
| title_full | Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity |
| title_fullStr | Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity |
| title_full_unstemmed | Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity |
| title_short | Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE–RAGE Binding Activity |
| title_sort | fermented fish collagen diminished photoaging related collagen decrease by attenuating age rage binding activity |
| topic | advanced glycation end products AGE–RAGE binding activity fermented fish collagen |
| url | https://www.mdpi.com/1467-3045/46/12/860 |
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