Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence
Exosomes, nano-sized extracellular vesicles secreted by all varieties of living cells, have emerged as pivotal mediators of intercellular communication within the tumor microenvironment. While exosomes significantly contribute to tumor progression, metastasis, immune modulation, and resistance to th...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-07-01
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| Series: | The EuroBiotech Journal |
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| Online Access: | https://doi.org/10.2478/ebtj-2025-0018 |
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| author | Yildirim Duygu T. Baki Yildirim A. Salzet Michel Bertelli Matteo Beccari Tommaso Prakash Satya Pascucci Luisa Dundar Munis |
| author_facet | Yildirim Duygu T. Baki Yildirim A. Salzet Michel Bertelli Matteo Beccari Tommaso Prakash Satya Pascucci Luisa Dundar Munis |
| author_sort | Yildirim Duygu T. |
| collection | DOAJ |
| description | Exosomes, nano-sized extracellular vesicles secreted by all varieties of living cells, have emerged as pivotal mediators of intercellular communication within the tumor microenvironment. While exosomes significantly contribute to tumor progression, metastasis, immune modulation, and resistance to therapy, the mechanisms of cargo selection and clinical translation remain controversial and insufficiently resolved. Recent high-throughput technologies have enabled detailed profiling of exosomal cargo; however, substantial challenges persist in their clinical application due to issues in isolation and standardization. This review systematically dissects these molecular biogenesis controversies, the roles of tumor-derived exosomes in modulating angiogenesis, immune escape, metastasis, and therapy resistance, and critically evaluates barriers hindering their clinical adoption. |
| format | Article |
| id | doaj-art-944981dc3cfe42fa9f68040d81e082c4 |
| institution | Kabale University |
| issn | 2564-615X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The EuroBiotech Journal |
| spelling | doaj-art-944981dc3cfe42fa9f68040d81e082c42025-08-20T03:28:13ZengSciendoThe EuroBiotech Journal2564-615X2025-07-019321623710.2478/ebtj-2025-0018Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competenceYildirim Duygu T.0Baki Yildirim A.1Salzet Michel2Bertelli Matteo3Beccari Tommaso4Prakash Satya5Pascucci Luisa6Dundar Munis71Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Türkiye1Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Türkiye2University of Lille, Inserm, University Hospital Center (CHU) Lille, U1192-Proteomics Inflammatory Response Mass Spectrometry (PRISM), Lille, FranceInstitut Universitaire de4MAGI EUREGIO, Bolzano, Italy5Department of Pharmaceutical Science, University of Perugia, Perugia, Italy6Department of Biomedical Engineering, McGill University, Montreal, Canada7Department of Veterinary Medicine, University of Perugia, Italy1Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, TürkiyeExosomes, nano-sized extracellular vesicles secreted by all varieties of living cells, have emerged as pivotal mediators of intercellular communication within the tumor microenvironment. While exosomes significantly contribute to tumor progression, metastasis, immune modulation, and resistance to therapy, the mechanisms of cargo selection and clinical translation remain controversial and insufficiently resolved. Recent high-throughput technologies have enabled detailed profiling of exosomal cargo; however, substantial challenges persist in their clinical application due to issues in isolation and standardization. This review systematically dissects these molecular biogenesis controversies, the roles of tumor-derived exosomes in modulating angiogenesis, immune escape, metastasis, and therapy resistance, and critically evaluates barriers hindering their clinical adoption.https://doi.org/10.2478/ebtj-2025-0018exosomesoncologyprecision medicinetumor nichemolecular communication |
| spellingShingle | Yildirim Duygu T. Baki Yildirim A. Salzet Michel Bertelli Matteo Beccari Tommaso Prakash Satya Pascucci Luisa Dundar Munis Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence The EuroBiotech Journal exosomes oncology precision medicine tumor niche molecular communication |
| title | Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence |
| title_full | Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence |
| title_fullStr | Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence |
| title_full_unstemmed | Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence |
| title_short | Messaging malignancy: Tumour-derived exosomes at the nexus of immune escape, vascular remodelling and metastatic competence |
| title_sort | messaging malignancy tumour derived exosomes at the nexus of immune escape vascular remodelling and metastatic competence |
| topic | exosomes oncology precision medicine tumor niche molecular communication |
| url | https://doi.org/10.2478/ebtj-2025-0018 |
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