CHARACTERISTIC FEATURES OF THE CLINICAL COURSE OF CHRONIC PARENCHYMAL MUMPS IN CHILDREN DURING EXACERBATION
Due to the fact that the etiology and pathogenesis of parenchymal mumps are not well understood, there is an urgent need for further study of individual components of the mechanisms that play a significant role in the manifestation of chronic inflammation in the parotid salivary glands. The publ...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Poltava State Medical University
2025-06-01
|
| Series: | Український стоматологічний альманах |
| Subjects: | |
| Online Access: | https://dental-almanac.org/index.php/journal/article/view/735 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Due to the fact that the etiology and pathogenesis of parenchymal mumps are not well understood, there is an urgent need for further study of individual components of the mechanisms that play a significant role in the manifestation of chronic inflammation in the parotid salivary glands.
The publication is based on the results of the examination and treatment of 57 children in the acute phase of chronic parenchymal mumps. A general clinical examination was performed, salivation rate was studied, oral fluid pH was measured, optical density, viscosity, α-amylase activity, level of average mass molecules, sialic acids and total protein were determined.
On external examination of patients with active disease, all patients had significant swelling in the area of the parotid glands projection, with palpable dense, tuberous glands. The mucous membrane around the mouths of the glandular excretory ducts involved in inflammation was swollen and hyperemic in all patients, and in 12 patients the duct mouth was gaping. When the glands were massaged, a viscous secretion was released from the ducts with a significant number of whitish plugs and flake-like inclusions, and no secretion was obtained from 5 glands. In the inactive course, a slight swelling was detected in the area of the gland localization. The salivary papilla was swollen, and when the glands were massaged, a viscous secretion was released from the ducts in a moderate amount with small, whitish inclusions.
During the initial examination of patients at the time of exacerbation of the inflammatory process, under conditions of active course, a decrease in the rate of salivation and pH in the oral fluid by 1.7 and 1.4 times was recorded, compared with the control group. The values of optical density and viscosity increased by 1.9 and 1.18 times, and in parallel, the activity of α-amylase increased by 1.4 times, and the content of medium molecules, sialic acids, and total protein had a pronounced tendency to increase by 1.6, 3.2, and 1.9 times, respectively. At this time, in patients with an inactive course, the salivation rate and pH level of the oral fluid decreased by 1.4 and 1.3 times. At the same time, the optical density and viscosity were 1.5 and 1.4 times higher than the control values, with an increased α-amylase activity of 1.3 times. The level of average mass molecules, sialic acids, and total protein exceeded the levels of patients in the control group by 1.5, 2.5, and 1.4 times, respectively.
Upon completion of the elimination of clinical manifestations of exacerbation in the active course of the disease, all physicochemical and biochemical constants improved, but the optical density, sialic acid and total protein content differed by 1.2 times compared with the results of the initial examination, and the level of average mass molecules by 1.5 times.
Taking into account the rather pronounced differences in the clinical manifestation of exacerbation of chronic parenchymal mumps in its active and inactive course, a differentiated approach to the prescription of pharmacological drugs to children to eliminate the manifestations of the inflammatory reaction should be taken. It is planned to establish the effectiveness of the treatment measures proposed by us.
|
|---|---|
| ISSN: | 2409-0255 2410-1427 |