Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network.
<h4>Background</h4>The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during...
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Public Library of Science (PLoS)
2016-01-01
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| author | Joan Puig-Barberà Angels Natividad-Sancho Svetlana Trushakova Anna Sominina Maria Pisareva Meral A Ciblak Selim Badur Hongjie Yu Benjamin J Cowling Clotilde El Guerche-Séblain Ainara Mira-Iglesias Lidiya Kisteneva Kirill Stolyarov Kubra Yurtcu Luzhao Feng Xavier López-Labrador Elena Burtseva Global Influenza Hospital Surveillance Study Group (GIHSN) |
| author_facet | Joan Puig-Barberà Angels Natividad-Sancho Svetlana Trushakova Anna Sominina Maria Pisareva Meral A Ciblak Selim Badur Hongjie Yu Benjamin J Cowling Clotilde El Guerche-Séblain Ainara Mira-Iglesias Lidiya Kisteneva Kirill Stolyarov Kubra Yurtcu Luzhao Feng Xavier López-Labrador Elena Burtseva Global Influenza Hospital Surveillance Study Group (GIHSN) |
| author_sort | Joan Puig-Barberà |
| collection | DOAJ |
| description | <h4>Background</h4>The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.<h4>Methods</h4>Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.<h4>Findings</h4>5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).<h4>Conclusions</h4>Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission. |
| format | Article |
| id | doaj-art-944182ca3f3641d3aa37d3bb9108ddb7 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-944182ca3f3641d3aa37d3bb9108ddb72025-08-20T02:15:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015497010.1371/journal.pone.0154970Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network.Joan Puig-BarberàAngels Natividad-SanchoSvetlana TrushakovaAnna SomininaMaria PisarevaMeral A CiblakSelim BadurHongjie YuBenjamin J CowlingClotilde El Guerche-SéblainAinara Mira-IglesiasLidiya KistenevaKirill StolyarovKubra YurtcuLuzhao FengXavier López-LabradorElena BurtsevaGlobal Influenza Hospital Surveillance Study Group (GIHSN)<h4>Background</h4>The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.<h4>Methods</h4>Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.<h4>Findings</h4>5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).<h4>Conclusions</h4>Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154970&type=printable |
| spellingShingle | Joan Puig-Barberà Angels Natividad-Sancho Svetlana Trushakova Anna Sominina Maria Pisareva Meral A Ciblak Selim Badur Hongjie Yu Benjamin J Cowling Clotilde El Guerche-Séblain Ainara Mira-Iglesias Lidiya Kisteneva Kirill Stolyarov Kubra Yurtcu Luzhao Feng Xavier López-Labrador Elena Burtseva Global Influenza Hospital Surveillance Study Group (GIHSN) Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. PLoS ONE |
| title | Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. |
| title_full | Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. |
| title_fullStr | Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. |
| title_full_unstemmed | Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. |
| title_short | Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network. |
| title_sort | epidemiology of hospital admissions with influenza during the 2013 2014 northern hemisphere influenza season results from the global influenza hospital surveillance network |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0154970&type=printable |
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