Sophoricoside reduces inflammation in type II collagen-induced arthritis by downregulating NLRP3 signaling

Sophoricoside reduces inflammation in type II collagen-induced arthritis by downregulating NLRP3 signaling

Immune responses, especially NLRP3 signaling in macrophages, play critical roles in rheumatoid arthritis (RA), an autoimmune and inflammatory disease. In this study, we aimed to identify novel therapies for RA. We focused on sophoricoside (SOP), an isoflavone glycoside isolated from Sophora japonica...

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Bibliographic Details
Main Authors: Youyang Liu, Yunlu Zhao, Qi Guo, Pengfei Wang, Peixuan Li, Qingqing Du, Huazhou Xu, Qingyin Yu, Xiaoyi Zhao, Weiya Zhang, Shengjun An, Shuhui Wu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Sophoricoside
Rheumatoid arthritis
Collagen-induced arthritis
Inflammation
Macrophages
NLRP3
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824002310
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