A versatile CRISPR/Cas9 system off-target prediction tool using language model

A versatile CRISPR/Cas9 system off-target prediction tool using language model

Abstract Genome editing with the CRISPR/Cas9 system has revolutionized life and medical sciences, particularly in treating monogenic genetic diseases by enabling long-term therapeutic effects from a single intervention. However, the CRISPR/Cas9 system can tolerate mismatches and DNA/RNA bulges at ta...

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Bibliographic Details
Main Authors: Weian Du, Liang Zhao, Kaichuan Diao, Yangyang Zheng, Qianyong Yang, Zhenzhen Zhu, Xiangxing Zhu, Dongsheng Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08275-6
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