Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review
ObjectiveTo identify independent risk factors and predictive markers for acute pancreatitis (AP) in patients with diabetic ketoacidosis (DKA).MethodsHere, we reported a 11-year experience in a single tertiary medical center and conduct a systematic review of acute pancreatitis in diabetic ketoacidos...
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Frontiers Media S.A.
2025-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1571631/full |
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| author | Yifei Chen Yan Bo Zhuanzhuan Han Mengjie Chen |
| author_facet | Yifei Chen Yan Bo Zhuanzhuan Han Mengjie Chen |
| author_sort | Yifei Chen |
| collection | DOAJ |
| description | ObjectiveTo identify independent risk factors and predictive markers for acute pancreatitis (AP) in patients with diabetic ketoacidosis (DKA).MethodsHere, we reported a 11-year experience in a single tertiary medical center and conduct a systematic review of acute pancreatitis in diabetic ketoacidosis patients (DKA-AP). 1,941 cases were included. First retrospective cohort study analyzed clinical data from 45 patients with DKA-AP and 45 matched controls with DKA alone (DKA-nonAP) admitted to Yangzhou University Affiliated Hospital (2013–2024). Baseline characteristics included BMI, hyperlipidemia history, and serological profiles. Secondly we retrieved clinical studies of DKA-AP from PubMed database system and analyzed these clinical data in depth.ResultsSignificant differences were observed in BMI: median [IQR] = 26.30 [22.15–28.40] vs. 23.20 [20.70–25.35] kg/m2, p = 0.031, hyperlipidemia history (26.7% vs. 4.4%, p = 0.004), abdominal pain duration (3 vs. 0 days, p < 0.001), and lipid profiles TC: median [IQR] = 7.71 [5.60–11.66] vs. 4.86 [4.22–6.52] mmol/L, p < 0.001; TG: median [IQR] = 11.90 [4.71–15.84] vs. 1.60 [0.89–3.64] mmol/L, p < 0.001. Logistic regression identified TC (OR = 1.455, 95% CI: 1.196–1.769), TG (OR = 2.046, 95% CI: 1.202–3.484), and abdominal pain duration (OR = 3.892, 95% CI: 2.173–6.972) as independent risk factors. Receiver operating characteristic curve (ROC) analysis demonstrated strong predictive performance (combined AUC = 0.933, sensitivity = 93.3%, specificity = 73.3%). Moreover, we found 11 clinical studies investigating DKA-AP. Cumulatively, 1,851 patients were studied, including 3 interventional studies, 1 genetic observational study, and 7 cohort studies exploring risk factors.ConclusionElevated TC, TG, and prolonged abdominal pain duration are key predictors of DKA-AP. These factors enhance early diagnosis and clinical management in Yangzhou, China. |
| format | Article |
| id | doaj-art-9436d6bef8234fec90a04088b762c0ee |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-9436d6bef8234fec90a04088b762c0ee2025-08-20T01:54:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15716311571631Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature reviewYifei Chen0Yan Bo1Zhuanzhuan Han2Mengjie Chen3The Department of Emergency Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, ChinaThe Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, ChinaThe Department of Emergency Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, ChinaThe Department of Medicine, Dalian Medical University, Dalian, Liaoning, ChinaObjectiveTo identify independent risk factors and predictive markers for acute pancreatitis (AP) in patients with diabetic ketoacidosis (DKA).MethodsHere, we reported a 11-year experience in a single tertiary medical center and conduct a systematic review of acute pancreatitis in diabetic ketoacidosis patients (DKA-AP). 1,941 cases were included. First retrospective cohort study analyzed clinical data from 45 patients with DKA-AP and 45 matched controls with DKA alone (DKA-nonAP) admitted to Yangzhou University Affiliated Hospital (2013–2024). Baseline characteristics included BMI, hyperlipidemia history, and serological profiles. Secondly we retrieved clinical studies of DKA-AP from PubMed database system and analyzed these clinical data in depth.ResultsSignificant differences were observed in BMI: median [IQR] = 26.30 [22.15–28.40] vs. 23.20 [20.70–25.35] kg/m2, p = 0.031, hyperlipidemia history (26.7% vs. 4.4%, p = 0.004), abdominal pain duration (3 vs. 0 days, p < 0.001), and lipid profiles TC: median [IQR] = 7.71 [5.60–11.66] vs. 4.86 [4.22–6.52] mmol/L, p < 0.001; TG: median [IQR] = 11.90 [4.71–15.84] vs. 1.60 [0.89–3.64] mmol/L, p < 0.001. Logistic regression identified TC (OR = 1.455, 95% CI: 1.196–1.769), TG (OR = 2.046, 95% CI: 1.202–3.484), and abdominal pain duration (OR = 3.892, 95% CI: 2.173–6.972) as independent risk factors. Receiver operating characteristic curve (ROC) analysis demonstrated strong predictive performance (combined AUC = 0.933, sensitivity = 93.3%, specificity = 73.3%). Moreover, we found 11 clinical studies investigating DKA-AP. Cumulatively, 1,851 patients were studied, including 3 interventional studies, 1 genetic observational study, and 7 cohort studies exploring risk factors.ConclusionElevated TC, TG, and prolonged abdominal pain duration are key predictors of DKA-AP. These factors enhance early diagnosis and clinical management in Yangzhou, China.https://www.frontiersin.org/articles/10.3389/fmed.2025.1571631/fulldiabetic ketoacidosisacute pancreatitispancreatitisrisk factorsdiagnosis |
| spellingShingle | Yifei Chen Yan Bo Zhuanzhuan Han Mengjie Chen Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review Frontiers in Medicine diabetic ketoacidosis acute pancreatitis pancreatitis risk factors diagnosis |
| title | Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review |
| title_full | Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review |
| title_fullStr | Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review |
| title_full_unstemmed | Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review |
| title_short | Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review |
| title_sort | risk factors associated with acute pancreatitis in diabetic ketoacidosis patients a 11 year experience in a single tertiary medical center and comprehensive literature review |
| topic | diabetic ketoacidosis acute pancreatitis pancreatitis risk factors diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1571631/full |
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