Signal and modulating role of enzymes of digestive glands
The aim of review. To present literature data, to generalize cumulative experimental and clinical data of the author and his co-workers on effect of hydrolases of gastro-intestinal contents and circulating blood on digestive organs functions.Original positions. The role of enzymes of digestive gland...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2011-03-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1384 |
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| _version_ | 1823860214269476864 |
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| author | G. F. Korotko |
| author_facet | G. F. Korotko |
| author_sort | G. F. Korotko |
| collection | DOAJ |
| description | The aim of review. To present literature data, to generalize cumulative experimental and clinical data of the author and his co-workers on effect of hydrolases of gastro-intestinal contents and circulating blood on digestive organs functions.Original positions. The role of enzymes of digestive glands is not limited to depolymerisation of nutrients, inactivation of antigens and bacteriostatic action. They carry out also signaling role in modulation of exo- and endocrine secretions of digestive glands and motor activity of gastro-intestinal tract. Proteinases realize effects through protease-activated receptors of four types which are localized on membranes of glandular cells, leiomyocytes, sensory terminals of afferent neurons and neuroendocrine producers of regulatory peptides, yielding direct and mediated morphofunctional effects.Conclusion. Enzymergic regulation of visceral functions, including sensory, alimentiry, protective, acts as new section of up-to-date science and, according to accumulated facts, is promising in gastroenterology, pancreatology, oncology, immunology and other segments of clinical medicine. |
| format | Article |
| id | doaj-art-9435e0977e2f4c8580c99a3a76a45cbd |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-03-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-9435e0977e2f4c8580c99a3a76a45cbd2025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-03-01212413938Signal and modulating role of enzymes of digestive glandsG. F. Korotko0Краснодарское многопрофильное лечебно-диагностическое объединение)The aim of review. To present literature data, to generalize cumulative experimental and clinical data of the author and his co-workers on effect of hydrolases of gastro-intestinal contents and circulating blood on digestive organs functions.Original positions. The role of enzymes of digestive glands is not limited to depolymerisation of nutrients, inactivation of antigens and bacteriostatic action. They carry out also signaling role in modulation of exo- and endocrine secretions of digestive glands and motor activity of gastro-intestinal tract. Proteinases realize effects through protease-activated receptors of four types which are localized on membranes of glandular cells, leiomyocytes, sensory terminals of afferent neurons and neuroendocrine producers of regulatory peptides, yielding direct and mediated morphofunctional effects.Conclusion. Enzymergic regulation of visceral functions, including sensory, alimentiry, protective, acts as new section of up-to-date science and, according to accumulated facts, is promising in gastroenterology, pancreatology, oncology, immunology and other segments of clinical medicine.https://www.gastro-j.ru/jour/article/view/1384digestive glandsenzymesexocrine secretionendocrine secretionprotease-activated receptors |
| spellingShingle | G. F. Korotko Signal and modulating role of enzymes of digestive glands Российский журнал гастроэнтерологии, гепатологии, колопроктологии digestive glands enzymes exocrine secretion endocrine secretion protease-activated receptors |
| title | Signal and modulating role of enzymes of digestive glands |
| title_full | Signal and modulating role of enzymes of digestive glands |
| title_fullStr | Signal and modulating role of enzymes of digestive glands |
| title_full_unstemmed | Signal and modulating role of enzymes of digestive glands |
| title_short | Signal and modulating role of enzymes of digestive glands |
| title_sort | signal and modulating role of enzymes of digestive glands |
| topic | digestive glands enzymes exocrine secretion endocrine secretion protease-activated receptors |
| url | https://www.gastro-j.ru/jour/article/view/1384 |
| work_keys_str_mv | AT gfkorotko signalandmodulatingroleofenzymesofdigestiveglands |