Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis
The purpose of the research is to determine the therapeutic efficiency of the moxidectin-based domestic anthelmintics and develop protocol of medical and preventive activities in dog's dirofilariasis under the conditions of Central Black Earth Region of Russia. Materials and methods. Blood from...
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Federal Scientific Centre VIEV
2019-10-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/485 |
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| author | N. S. Bespalova T. A. Zolotykh E. O. Vozgorkova |
| author_facet | N. S. Bespalova T. A. Zolotykh E. O. Vozgorkova |
| author_sort | N. S. Bespalova |
| collection | DOAJ |
| description | The purpose of the research is to determine the therapeutic efficiency of the moxidectin-based domestic anthelmintics and develop protocol of medical and preventive activities in dog's dirofilariasis under the conditions of Central Black Earth Region of Russia. Materials and methods. Blood from ill dogs infected naturally with both species of dirofilariases that was tested for presence of helminths' larvae by Millipore® (Ireland) membrane filter method served as the material for the research. Experimental groups were formed out of 76 infected with dirofilariasis dogs aged 1-14 years under the principle of analogs to determine the therapeutic efficiency of moxidectin-based domestic anthelmintics. Drugs weren’t administered into intact animals of the first group (n = 21). MKTc Ankir-B® in the dose of 500 mg per animal was administered orally to animals of the second group (n = 19) as placebo. Inspector Total C anthelmintic was administered in the single dose of 2.5 mg per kg of body weight to the third group of dogs (n = 19) epidermally, Helmimax anthelmintic was administered in the single dose of 0.25 mg per kg of body weight orally to animals of the fourth group (n = 17). During experiments animals were examined clinically and hemolarvoscopically before administration of drugs and on the 3rd, 14th, 30th, 45th and 60th day after administration. Results and discussion. Inspector Total C anthelmintic in the dose of 2.5 mg per kg according to an active substance in the form of spot-on and Helmimax anthelmintic in the dose of 0.25 mg per kg according to an active substance in single administration in dogs infected with Dirofilaria immitis and D. repens species dirofilariasis have 100 % microfilaricidal efficiency. Anthelmintics do not change physiological parameters, do not cause side effects and well tolerated by animals. It should be noted that drugs therapeutic action starts on the third day after treatment regardless of the infection intensity and germ's species. Complete demolition of dirofilariasis adult stages are achieved in chronic administration during 6 months (once per month). |
| format | Article |
| id | doaj-art-9435ab0bfba1401b9c8a560fd431146b |
| institution | Kabale University |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| publishDate | 2019-10-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj-art-9435ab0bfba1401b9c8a560fd431146b2025-08-20T03:59:17ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432019-10-01123828610.31016/1998-8435-2018-12-3-82-86482Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's DirofilariosisN. S. Bespalova0T. A. Zolotykh1E. O. Vozgorkova2Voronezh State Agrarian University named after Emperor Peter the GreatVoronezh State Agrarian University named after Emperor Peter the GreatVoronezh State Agrarian University named after Emperor Peter the GreatThe purpose of the research is to determine the therapeutic efficiency of the moxidectin-based domestic anthelmintics and develop protocol of medical and preventive activities in dog's dirofilariasis under the conditions of Central Black Earth Region of Russia. Materials and methods. Blood from ill dogs infected naturally with both species of dirofilariases that was tested for presence of helminths' larvae by Millipore® (Ireland) membrane filter method served as the material for the research. Experimental groups were formed out of 76 infected with dirofilariasis dogs aged 1-14 years under the principle of analogs to determine the therapeutic efficiency of moxidectin-based domestic anthelmintics. Drugs weren’t administered into intact animals of the first group (n = 21). MKTc Ankir-B® in the dose of 500 mg per animal was administered orally to animals of the second group (n = 19) as placebo. Inspector Total C anthelmintic was administered in the single dose of 2.5 mg per kg of body weight to the third group of dogs (n = 19) epidermally, Helmimax anthelmintic was administered in the single dose of 0.25 mg per kg of body weight orally to animals of the fourth group (n = 17). During experiments animals were examined clinically and hemolarvoscopically before administration of drugs and on the 3rd, 14th, 30th, 45th and 60th day after administration. Results and discussion. Inspector Total C anthelmintic in the dose of 2.5 mg per kg according to an active substance in the form of spot-on and Helmimax anthelmintic in the dose of 0.25 mg per kg according to an active substance in single administration in dogs infected with Dirofilaria immitis and D. repens species dirofilariasis have 100 % microfilaricidal efficiency. Anthelmintics do not change physiological parameters, do not cause side effects and well tolerated by animals. It should be noted that drugs therapeutic action starts on the third day after treatment regardless of the infection intensity and germ's species. Complete demolition of dirofilariasis adult stages are achieved in chronic administration during 6 months (once per month).https://vniigis.elpub.ru/jour/article/view/485дирофиляриозантигельминтикимоксидектиныdirofilaria repensd. immitis«инспектор тотал с»гельмимакслечениепрофилактикаdirofilariosisanthelminticsmoxidectinsdirofilaria immitisd. immitisinspector total chelmimaxtreatmentprophylaxis |
| spellingShingle | N. S. Bespalova T. A. Zolotykh E. O. Vozgorkova Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis Российский паразитологический журнал дирофиляриоз антигельминтики моксидектины dirofilaria repens d. immitis «инспектор тотал с» гельмимакс лечение профилактика dirofilariosis anthelmintics moxidectins dirofilaria immitis d. immitis inspector total c helmimax treatment prophylaxis |
| title | Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis |
| title_full | Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis |
| title_fullStr | Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis |
| title_full_unstemmed | Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis |
| title_short | Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis |
| title_sort | therapeutic efficiency of domestic moxidectins in the cases of dog s dirofilariosis |
| topic | дирофиляриоз антигельминтики моксидектины dirofilaria repens d. immitis «инспектор тотал с» гельмимакс лечение профилактика dirofilariosis anthelmintics moxidectins dirofilaria immitis d. immitis inspector total c helmimax treatment prophylaxis |
| url | https://vniigis.elpub.ru/jour/article/view/485 |
| work_keys_str_mv | AT nsbespalova therapeuticefficiencyofdomesticmoxidectinsinthecasesofdogsdirofilariosis AT tazolotykh therapeuticefficiencyofdomesticmoxidectinsinthecasesofdogsdirofilariosis AT eovozgorkova therapeuticefficiencyofdomesticmoxidectinsinthecasesofdogsdirofilariosis |