Research Progresses in Vitrification by Minimum Volume Method

Vitrification is an effective method in the field of cryopreservation since it can prevent the formation of ice crystals. Vitrification requires ultra-fast cooling rates and high concentrations of cryoprotective agents. However, osmotic injury and toxic damage can be caused by high concentration of...

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Main Authors: Zhang Xiaomin, Zhou Xinli
Format: Article
Language:zho
Published: Journal of Refrigeration Magazines Agency Co., Ltd. 2018-01-01
Series:Zhileng xuebao
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Online Access:http://www.zhilengxuebao.com/thesisDetails#10.3969/j.issn.0253-4339.2018.04.063
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author Zhang Xiaomin
Zhou Xinli
author_facet Zhang Xiaomin
Zhou Xinli
author_sort Zhang Xiaomin
collection DOAJ
description Vitrification is an effective method in the field of cryopreservation since it can prevent the formation of ice crystals. Vitrification requires ultra-fast cooling rates and high concentrations of cryoprotective agents. However, osmotic injury and toxic damage can be caused by high concentration of cryoprotective agents. The minimum volume methods can significantly increase the cooling rate and reduce the concentration of cryoprotective agents in vitrification. In this paper, the latest research progresses in vitrification by minimum volume methods are reviewed. The minimum volume methods include carrier-based droplet vitrification, spray droplet vitrification, bio-printing droplet vitrification, and microfluidic encapsulation droplet vitrification. Among these, spray droplet vitrification, bio-printing droplet vitrification, and microfluidic encapsulation droplet vitrification are the combination of emerging droplet generation technology and vitrification technology. Because of the rapid generation of uniform droplets and high throughput, they have great potential in the field of cryopreservation.
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issn 0253-4339
language zho
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publisher Journal of Refrigeration Magazines Agency Co., Ltd.
record_format Article
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spelling doaj-art-943573f47daf4f6da91ce48410adb0fd2025-08-20T03:16:29ZzhoJournal of Refrigeration Magazines Agency Co., Ltd.Zhileng xuebao0253-43392018-01-013966512583Research Progresses in Vitrification by Minimum Volume MethodZhang XiaominZhou XinliVitrification is an effective method in the field of cryopreservation since it can prevent the formation of ice crystals. Vitrification requires ultra-fast cooling rates and high concentrations of cryoprotective agents. However, osmotic injury and toxic damage can be caused by high concentration of cryoprotective agents. The minimum volume methods can significantly increase the cooling rate and reduce the concentration of cryoprotective agents in vitrification. In this paper, the latest research progresses in vitrification by minimum volume methods are reviewed. The minimum volume methods include carrier-based droplet vitrification, spray droplet vitrification, bio-printing droplet vitrification, and microfluidic encapsulation droplet vitrification. Among these, spray droplet vitrification, bio-printing droplet vitrification, and microfluidic encapsulation droplet vitrification are the combination of emerging droplet generation technology and vitrification technology. Because of the rapid generation of uniform droplets and high throughput, they have great potential in the field of cryopreservation.http://www.zhilengxuebao.com/thesisDetails#10.3969/j.issn.0253-4339.2018.04.063minimum volume methodsvitrificationspray dropletbio-printingmicrofluidic encapsulation
spellingShingle Zhang Xiaomin
Zhou Xinli
Research Progresses in Vitrification by Minimum Volume Method
Zhileng xuebao
minimum volume methods
vitrification
spray droplet
bio-printing
microfluidic encapsulation
title Research Progresses in Vitrification by Minimum Volume Method
title_full Research Progresses in Vitrification by Minimum Volume Method
title_fullStr Research Progresses in Vitrification by Minimum Volume Method
title_full_unstemmed Research Progresses in Vitrification by Minimum Volume Method
title_short Research Progresses in Vitrification by Minimum Volume Method
title_sort research progresses in vitrification by minimum volume method
topic minimum volume methods
vitrification
spray droplet
bio-printing
microfluidic encapsulation
url http://www.zhilengxuebao.com/thesisDetails#10.3969/j.issn.0253-4339.2018.04.063
work_keys_str_mv AT zhangxiaomin researchprogressesinvitrificationbyminimumvolumemethod
AT zhouxinli researchprogressesinvitrificationbyminimumvolumemethod