Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma
We aimed to evaluate long-term toxicity in children with medulloblastoma treated with postoperative radiotherapy (RT). This study included 21 patients aged 4-16 who had been diagnosed with medulloblastoma. All of the patients in the study received postoperative craniospinal RT. Postoperative...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2015-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1213 |
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| _version_ | 1850236608552370176 |
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| author | Oya Karadağ Candan Demiröz Abakay Lütfi Özkan Halil Sağlam Metin Demirkaya |
| author_facet | Oya Karadağ Candan Demiröz Abakay Lütfi Özkan Halil Sağlam Metin Demirkaya |
| author_sort | Oya Karadağ |
| collection | DOAJ |
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We aimed to evaluate long-term toxicity in children with medulloblastoma treated with postoperative radiotherapy (RT). This study included 21 patients aged 4-16 who had been diagnosed with medulloblastoma. All of the patients in the study received postoperative craniospinal RT. Postoperative RT followed by chemotherapy was the treatment protocol. A total of 13 patients (62%) received chemotherapy concurrently with RT. Overall survival was 50 months (range, 1-169 months) and disease-free survival was 39 months (range, 4-171 months). In the data analysis, the heights of 11 patients (91.6%) were found to be below 50% on the height curve, and 8 (66.6%) patients had weights below 50% on the weight curve. Mean sitting height was 72.58 ± 6.33 cm, and this was statistically correlated with parameters such as LH level (p=0.037), testosterone level (p=0.020), height (p=0.002), weight (p=0.033) and age at diagnosis (p=0.002). Radiation therapy for medulloblastoma seems to have a late toxic effect on long-term survivors. With the improving survival rate of medulloblastoma patients, RT doses should be as low as possible without sacrificing efficacy.
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| format | Article |
| id | doaj-art-9432fcb58b53431db394017372ac092f |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-9432fcb58b53431db394017372ac092f2025-08-20T02:01:55ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-04-01572Evaluation of late effects of postoperative radiotherapy in patients with medulloblastomaOya Karadağ0Candan Demiröz AbakayLütfi ÖzkanHalil SağlamMetin DemirkayaAlanya State Hospital, Department of Radiation Oncology, Antalya, Turkey. doccandan@yahoo.com. We aimed to evaluate long-term toxicity in children with medulloblastoma treated with postoperative radiotherapy (RT). This study included 21 patients aged 4-16 who had been diagnosed with medulloblastoma. All of the patients in the study received postoperative craniospinal RT. Postoperative RT followed by chemotherapy was the treatment protocol. A total of 13 patients (62%) received chemotherapy concurrently with RT. Overall survival was 50 months (range, 1-169 months) and disease-free survival was 39 months (range, 4-171 months). In the data analysis, the heights of 11 patients (91.6%) were found to be below 50% on the height curve, and 8 (66.6%) patients had weights below 50% on the weight curve. Mean sitting height was 72.58 ± 6.33 cm, and this was statistically correlated with parameters such as LH level (p=0.037), testosterone level (p=0.020), height (p=0.002), weight (p=0.033) and age at diagnosis (p=0.002). Radiation therapy for medulloblastoma seems to have a late toxic effect on long-term survivors. With the improving survival rate of medulloblastoma patients, RT doses should be as low as possible without sacrificing efficacy. https://turkjpediatr.org/article/view/1213 |
| spellingShingle | Oya Karadağ Candan Demiröz Abakay Lütfi Özkan Halil Sağlam Metin Demirkaya Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma The Turkish Journal of Pediatrics |
| title | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| title_full | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| title_fullStr | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| title_full_unstemmed | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| title_short | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| title_sort | evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma |
| url | https://turkjpediatr.org/article/view/1213 |
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