Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments
The current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/2672740 |
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| author | Merlis P. Alvarez-Berríos Naisha Sosa-Cintron Mariel Rodriguez-Lugo Ridhima Juneja Juan L. Vivero-Escoto |
| author_facet | Merlis P. Alvarez-Berríos Naisha Sosa-Cintron Mariel Rodriguez-Lugo Ridhima Juneja Juan L. Vivero-Escoto |
| author_sort | Merlis P. Alvarez-Berríos |
| collection | DOAJ |
| description | The current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid nanoparticles, those based on mesoporous silica and iron oxide nanoparticles (MSNs and IONPs) have gained a privileged place in the biomedical field because of their outstanding properties. There are many studies demonstrating their effectiveness as drug delivery systems, nanoheaters, and imaging contrast agents. This review summarizes the advances related to the utilization of IONPs and MSNs for reducing side effects, overcoming MDR, and inhibiting metastasis. Furthermore, we give a future perspective of the clinical application of these technologies. |
| format | Article |
| id | doaj-art-94319e2dab9e4a2bba852f4c317f3d49 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-94319e2dab9e4a2bba852f4c317f3d492025-08-20T03:37:27ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/26727402672740Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer TreatmentsMerlis P. Alvarez-Berríos0Naisha Sosa-Cintron1Mariel Rodriguez-Lugo2Ridhima Juneja3Juan L. Vivero-Escoto4Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Ponce, PR 00716, USADepartment of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Ponce, PR 00716, USADepartment of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Ponce, PR 00716, USADepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USADepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USAThe current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid nanoparticles, those based on mesoporous silica and iron oxide nanoparticles (MSNs and IONPs) have gained a privileged place in the biomedical field because of their outstanding properties. There are many studies demonstrating their effectiveness as drug delivery systems, nanoheaters, and imaging contrast agents. This review summarizes the advances related to the utilization of IONPs and MSNs for reducing side effects, overcoming MDR, and inhibiting metastasis. Furthermore, we give a future perspective of the clinical application of these technologies.http://dx.doi.org/10.1155/2016/2672740 |
| spellingShingle | Merlis P. Alvarez-Berríos Naisha Sosa-Cintron Mariel Rodriguez-Lugo Ridhima Juneja Juan L. Vivero-Escoto Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments Journal of Chemistry |
| title | Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments |
| title_full | Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments |
| title_fullStr | Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments |
| title_full_unstemmed | Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments |
| title_short | Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments |
| title_sort | hybrid nanomaterials based on iron oxide nanoparticles and mesoporous silica nanoparticles overcoming challenges in current cancer treatments |
| url | http://dx.doi.org/10.1155/2016/2672740 |
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