Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction
ObjectiveThe left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression. To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fr...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1501004/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850114660703928320 |
|---|---|
| author | Qingfeng Zhang Qingfeng Zhang Sijia Wang Sijia Wang Hongmei Zhang Kai Wang Wenhua Li Geqi Ding Luwei Ye Chunmei Li Yan Deng Yi Wang Lixue Yin Lixue Yin |
| author_facet | Qingfeng Zhang Qingfeng Zhang Sijia Wang Sijia Wang Hongmei Zhang Kai Wang Wenhua Li Geqi Ding Luwei Ye Chunmei Li Yan Deng Yi Wang Lixue Yin Lixue Yin |
| author_sort | Qingfeng Zhang |
| collection | DOAJ |
| description | ObjectiveThe left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression. To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe study involved 62 healthy subjects and 163 patients with HT (112 patients in simple HT group and 51 patients in HT-HFpEF group). Each patient performed exercise stress test and standard ultrasonic images were evaluated. A comprehensive evaluation of atrioventricular function, along with investigation into the correlation between these functional parameters and exercise capacity. And further to investigate the feasibility of predicting exercise intolerance using three-dimensional derived left atrial strain index (LASI) (E/e'/LASr and E/e'/LASr-c).ResultsCompared to healthy subjects, HT group demonstrated the elevation in left atrial volume accompanied by decrease in strain value (P < 0.05). In HT-HFpEF group, further significant reductions were observed in both longitudinal (LASr) and circumferential strain (LASr-c, LASct-c) (P < 0.05). Univariate regression demonstrated that both E/e'/LASr and E/e'/LASr-c were significantly correlated with metabolic equivalents (METs) (r = −0.462, P < 0.001; r = −0.381, P < 0.001). The E/e'/LASr demonstrates comparable diagnostic efficacy to exercise-E/e' in assessing exercise intolerance in HT-HFpEF patients (AUC: 0.836 vs. 0.867, P = 0.239).ConclusionProgressive LA remodeling contributes to decreased atrioventricular compliance in HT and HT-HFpEF patients.E/e'/LASr serves as an independent indicator of exercise intolerance in patients with HT-HFpEF. |
| format | Article |
| id | doaj-art-942f86bcd8e345178fc75ade7c0357a3 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-942f86bcd8e345178fc75ade7c0357a32025-08-20T02:36:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-12-011110.3389/fcvm.2024.15010041501004Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fractionQingfeng Zhang0Qingfeng Zhang1Sijia Wang2Sijia Wang3Hongmei Zhang4Kai Wang5Wenhua Li6Geqi Ding7Luwei Ye8Chunmei Li9Yan Deng10Yi Wang11Lixue Yin12Lixue Yin13School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Acute Care Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Cardiovascular Ultrasound and Key Laboratory in Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaObjectiveThe left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression. To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe study involved 62 healthy subjects and 163 patients with HT (112 patients in simple HT group and 51 patients in HT-HFpEF group). Each patient performed exercise stress test and standard ultrasonic images were evaluated. A comprehensive evaluation of atrioventricular function, along with investigation into the correlation between these functional parameters and exercise capacity. And further to investigate the feasibility of predicting exercise intolerance using three-dimensional derived left atrial strain index (LASI) (E/e'/LASr and E/e'/LASr-c).ResultsCompared to healthy subjects, HT group demonstrated the elevation in left atrial volume accompanied by decrease in strain value (P < 0.05). In HT-HFpEF group, further significant reductions were observed in both longitudinal (LASr) and circumferential strain (LASr-c, LASct-c) (P < 0.05). Univariate regression demonstrated that both E/e'/LASr and E/e'/LASr-c were significantly correlated with metabolic equivalents (METs) (r = −0.462, P < 0.001; r = −0.381, P < 0.001). The E/e'/LASr demonstrates comparable diagnostic efficacy to exercise-E/e' in assessing exercise intolerance in HT-HFpEF patients (AUC: 0.836 vs. 0.867, P = 0.239).ConclusionProgressive LA remodeling contributes to decreased atrioventricular compliance in HT and HT-HFpEF patients.E/e'/LASr serves as an independent indicator of exercise intolerance in patients with HT-HFpEF.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1501004/fullthree-dimensional speckle trackingleft atrialhypertensionstiffnessheart failure |
| spellingShingle | Qingfeng Zhang Qingfeng Zhang Sijia Wang Sijia Wang Hongmei Zhang Kai Wang Wenhua Li Geqi Ding Luwei Ye Chunmei Li Yan Deng Yi Wang Lixue Yin Lixue Yin Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction Frontiers in Cardiovascular Medicine three-dimensional speckle tracking left atrial hypertension stiffness heart failure |
| title | Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction |
| title_full | Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction |
| title_fullStr | Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction |
| title_full_unstemmed | Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction |
| title_short | Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction |
| title_sort | evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension related heart failure with preserved ejection fraction |
| topic | three-dimensional speckle tracking left atrial hypertension stiffness heart failure |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1501004/full |
| work_keys_str_mv | AT qingfengzhang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT qingfengzhang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT sijiawang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT sijiawang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT hongmeizhang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT kaiwang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT wenhuali evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT geqiding evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT luweiye evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT chunmeili evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT yandeng evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT yiwang evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT lixueyin evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction AT lixueyin evaluationofleftatrialfunctionandtherelationshipbetweenleftatrialstiffnessindexandexercisecapacityinhypertensionrelatedheartfailurewithpreservedejectionfraction |