Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches

Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches

BackgroundMetabolic disorder and endothelial dysfunction (ED) are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of Cardiovascular disease (CVD). The pathophysiology remains incompletely understood.MethodsLeftover serum samples were coll...

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Bibliographic Details
Main Authors: Qi Sun, Longchuan Xie, He An, Wei Chen, Qirong Yang, Peng Wang, Yijun Tang, Chunyan Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiovascular disease
endothelial dysfunction
lipid metabolism
EndMT
hub genes
bioinformatics analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1585030/full
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