The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia
Background: Hyperlipidemia, a condition marked by elevated levels of total cholesterol and related lipids, poses significant health risks. The potential cholesterol-lowering effects of Kersen leaves (Muntingia calabura L.), which are rich in flavonoids, saponins, and tannins, warrant investigation....
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2024-08-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/152 |
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| author | Sion Benu Anita Amat Arley Telussa Rr Listyawati Nurina |
| author_facet | Sion Benu Anita Amat Arley Telussa Rr Listyawati Nurina |
| author_sort | Sion Benu |
| collection | DOAJ |
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Background: Hyperlipidemia, a condition marked by elevated levels of total cholesterol and related lipids, poses significant health risks. The potential cholesterol-lowering effects of Kersen leaves (Muntingia calabura L.), which are rich in flavonoids, saponins, and tannins, warrant investigation. Despite the recognized benefits of Muntingia calabura L., its potential, particularly from the Nusa Tenggara Timur (NTT) region, still needs to be explored.
Objective: This study aimed to assess the effect of Kersen leaves extract, sourced from arid regions of NTT, on hypercholesterolemia in Mus musculus.
Methods: Healthy male white mice (Mus musculus) were used in the experiment and divided into five groups: a normal group, a negative control group, and three treatment groups receiving a high-cholesterol diet supplemented with Kersen leaves extract at doses of 75, 150, and 300 mg/kg body weight, respectively. Total cholesterol levels were measured using the Easy Touch GCU monitoring system. Statistical analysis was conducted using the Paired T Test to compare the pre and post data in each group.
Results: A high-cholesterol diet for 14 days significantly increased body weight and total cholesterol levels in male white mice (Mus musculus). Meanwhile, treatment with Kersen leaves extract at 300 mg/kg body weight effectively mitigated the elevation in cholesterol levels.
Conclusion: Kersen leaves extract (Muntingia calabura L.) significantly reduced hypercholesterolemia in Mus musculus, suggesting its potential as a natural therapeutic agent for cholesterol management. Further research is necessary to elucidate the underlying mechanisms of action and evaluate its clinical applicability.
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| format | Article |
| id | doaj-art-9418d6216b694a7ca1125483aecda617 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-9418d6216b694a7ca1125483aecda6172025-02-08T03:04:45ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222024-08-017110.32889/actabioina.152The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemiaSion Benu0Anita Amat1Arley Telussa2Rr Listyawati Nurina3Faculty of Medicine, Universitas Nusa CendanaDepartment of Biochemistry, Faculty of Medicine and Veterinary Medicine, Universitas Nusa CendanaDepartment of Surgery, Prof Dr WZ Yohanes Hospital, KupangDepartment of Pharmacology, Faculty of Medicine and Veterinary Medicine, Universitas Nusa Cendana Background: Hyperlipidemia, a condition marked by elevated levels of total cholesterol and related lipids, poses significant health risks. The potential cholesterol-lowering effects of Kersen leaves (Muntingia calabura L.), which are rich in flavonoids, saponins, and tannins, warrant investigation. Despite the recognized benefits of Muntingia calabura L., its potential, particularly from the Nusa Tenggara Timur (NTT) region, still needs to be explored. Objective: This study aimed to assess the effect of Kersen leaves extract, sourced from arid regions of NTT, on hypercholesterolemia in Mus musculus. Methods: Healthy male white mice (Mus musculus) were used in the experiment and divided into five groups: a normal group, a negative control group, and three treatment groups receiving a high-cholesterol diet supplemented with Kersen leaves extract at doses of 75, 150, and 300 mg/kg body weight, respectively. Total cholesterol levels were measured using the Easy Touch GCU monitoring system. Statistical analysis was conducted using the Paired T Test to compare the pre and post data in each group. Results: A high-cholesterol diet for 14 days significantly increased body weight and total cholesterol levels in male white mice (Mus musculus). Meanwhile, treatment with Kersen leaves extract at 300 mg/kg body weight effectively mitigated the elevation in cholesterol levels. Conclusion: Kersen leaves extract (Muntingia calabura L.) significantly reduced hypercholesterolemia in Mus musculus, suggesting its potential as a natural therapeutic agent for cholesterol management. Further research is necessary to elucidate the underlying mechanisms of action and evaluate its clinical applicability. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/152HypercholesterolemiaKersen leaves extractMus musculus |
| spellingShingle | Sion Benu Anita Amat Arley Telussa Rr Listyawati Nurina The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia Acta Biochimica Indonesiana Hypercholesterolemia Kersen leaves extract Mus musculus |
| title | The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia |
| title_full | The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia |
| title_fullStr | The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia |
| title_full_unstemmed | The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia |
| title_short | The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia |
| title_sort | impact of kersen leaves muntingia calabura l extract on mus musculus with hypercholesterolemia |
| topic | Hypercholesterolemia Kersen leaves extract Mus musculus |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/152 |
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