Basic principles of combination therapy: focus on drug-drug interaction
The article is devoted to the issue of drug interactions in the combination regimens. Today, when drug therapy is the first-line approach for patients with noncommunicable diseases, and the world population ageing leads to an increase in the number of patients with severe comorbidity and polypharmac...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2021-11-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408529822121984 |
|---|---|
| author | S. Yu. Martsevich Yu. V. Lukina O. M. Drapkina |
| author_facet | S. Yu. Martsevich Yu. V. Lukina O. M. Drapkina |
| author_sort | S. Yu. Martsevich |
| collection | DOAJ |
| description | The article is devoted to the issue of drug interactions in the combination regimens. Today, when drug therapy is the first-line approach for patients with noncommunicable diseases, and the world population ageing leads to an increase in the number of patients with severe comorbidity and polypharmacy, the problem of drug-drug interaction is especially relevant. The article discusses the main types of drug interactions — pharmacokinetic (related to absorption, distribution, metabolism and excretion of drugs) and pharmacodynamic ones, leading to synergy or antagonism of the pharmacological effects. The consequences of drug interactions can be desirable and undesirable, while the latter are much more common. Attention should be directed precisely to preventing such interactions. Also, using data from special scales and lists (Beers criteria, STOPP/START criteria), the options for various adverse drugdrug interactions are briefly described. In addition, the article provides a number of Internet resources that allow assessing the drug interaction risk when prescribing combination therapy. |
| format | Article |
| id | doaj-art-940c3b5889594a9a80d7856cc6a7a00a |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2021-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-940c3b5889594a9a80d7856cc6a7a00a2025-08-20T03:35:45Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-11-0120710.15829/1728-8800-2021-30312379Basic principles of combination therapy: focus on drug-drug interactionS. Yu. Martsevich0Yu. V. Lukina1O. M. Drapkina2National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineThe article is devoted to the issue of drug interactions in the combination regimens. Today, when drug therapy is the first-line approach for patients with noncommunicable diseases, and the world population ageing leads to an increase in the number of patients with severe comorbidity and polypharmacy, the problem of drug-drug interaction is especially relevant. The article discusses the main types of drug interactions — pharmacokinetic (related to absorption, distribution, metabolism and excretion of drugs) and pharmacodynamic ones, leading to synergy or antagonism of the pharmacological effects. The consequences of drug interactions can be desirable and undesirable, while the latter are much more common. Attention should be directed precisely to preventing such interactions. Also, using data from special scales and lists (Beers criteria, STOPP/START criteria), the options for various adverse drugdrug interactions are briefly described. In addition, the article provides a number of Internet resources that allow assessing the drug interaction risk when prescribing combination therapy.https://cardiovascular.elpub.ru/jour/article/view/3031combination therapydrug-drug interactionpharmacokineticspharmacodynamics |
| spellingShingle | S. Yu. Martsevich Yu. V. Lukina O. M. Drapkina Basic principles of combination therapy: focus on drug-drug interaction Кардиоваскулярная терапия и профилактика combination therapy drug-drug interaction pharmacokinetics pharmacodynamics |
| title | Basic principles of combination therapy: focus on drug-drug interaction |
| title_full | Basic principles of combination therapy: focus on drug-drug interaction |
| title_fullStr | Basic principles of combination therapy: focus on drug-drug interaction |
| title_full_unstemmed | Basic principles of combination therapy: focus on drug-drug interaction |
| title_short | Basic principles of combination therapy: focus on drug-drug interaction |
| title_sort | basic principles of combination therapy focus on drug drug interaction |
| topic | combination therapy drug-drug interaction pharmacokinetics pharmacodynamics |
| url | https://cardiovascular.elpub.ru/jour/article/view/3031 |
| work_keys_str_mv | AT syumartsevich basicprinciplesofcombinationtherapyfocusondrugdruginteraction AT yuvlukina basicprinciplesofcombinationtherapyfocusondrugdruginteraction AT omdrapkina basicprinciplesofcombinationtherapyfocusondrugdruginteraction |