Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers
Betel quid (BQ) products, with or without tobacco, have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. There a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/618032 |
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| author | Che-Yi Lin Tien-Szu Pan Chun-Chan Ting Shih-Shin Liang Shu-Hung Huang Hsiu-Yueh Liu Edward Cheng-Chuan Ko Chung-Wei Wu Jen-Yang Tang Ping-Ho Chen |
| author_facet | Che-Yi Lin Tien-Szu Pan Chun-Chan Ting Shih-Shin Liang Shu-Hung Huang Hsiu-Yueh Liu Edward Cheng-Chuan Ko Chung-Wei Wu Jen-Yang Tang Ping-Ho Chen |
| author_sort | Che-Yi Lin |
| collection | DOAJ |
| description | Betel quid (BQ) products, with or without tobacco, have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. There are estimated 600 million BQ users worldwide. In Taiwan alone there are 2 million habitual users (approximately 10% of the population). Oral and pharyngeal cancers result from interactions between genes and environmental factors (BQ exposure). Cytochrome p450 (CYP) families are implicated in the metabolic activation of BQ- and areca nut-specific nitrosamines. In this review, we summarize the current knowledge base regarding CYP genetic variants and related oral disorders. In clinical applications, we focus on cancers of the oral cavity and pharynx and OPMDs associated with CYP gene polymorphisms, including CYP1A1, CYP2A6, CYP2E1, and CYP26B1. Our discussion of CYP polymorphisms provides insight into the importance of screening tests in OPMDs patients for the prevention of oral and pharyngeal cancers. Future studies will establish a strong foundation for the development of chemoprevention strategies, polymorphism-based clinical diagnostic tools (e.g., specific single-nucleotide polymorphism (SNP) “barcodes”), and effective treatments for BQ-related oral disorders. |
| format | Article |
| id | doaj-art-940b08558d6645bab8029f0df06392ab |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-940b08558d6645bab8029f0df06392ab2025-02-03T06:07:13ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/618032618032Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal CancersChe-Yi Lin0Tien-Szu Pan1Chun-Chan Ting2Shih-Shin Liang3Shu-Hung Huang4Hsiu-Yueh Liu5Edward Cheng-Chuan Ko6Chung-Wei Wu7Jen-Yang Tang8Ping-Ho Chen9Department of Oral and Maxillofacial Surgery, Chi Mei Hospital, Liouying 736, TaiwanDepartment of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung 807, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDepartment of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanBetel quid (BQ) products, with or without tobacco, have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens that are associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. There are estimated 600 million BQ users worldwide. In Taiwan alone there are 2 million habitual users (approximately 10% of the population). Oral and pharyngeal cancers result from interactions between genes and environmental factors (BQ exposure). Cytochrome p450 (CYP) families are implicated in the metabolic activation of BQ- and areca nut-specific nitrosamines. In this review, we summarize the current knowledge base regarding CYP genetic variants and related oral disorders. In clinical applications, we focus on cancers of the oral cavity and pharynx and OPMDs associated with CYP gene polymorphisms, including CYP1A1, CYP2A6, CYP2E1, and CYP26B1. Our discussion of CYP polymorphisms provides insight into the importance of screening tests in OPMDs patients for the prevention of oral and pharyngeal cancers. Future studies will establish a strong foundation for the development of chemoprevention strategies, polymorphism-based clinical diagnostic tools (e.g., specific single-nucleotide polymorphism (SNP) “barcodes”), and effective treatments for BQ-related oral disorders.http://dx.doi.org/10.1155/2013/618032 |
| spellingShingle | Che-Yi Lin Tien-Szu Pan Chun-Chan Ting Shih-Shin Liang Shu-Hung Huang Hsiu-Yueh Liu Edward Cheng-Chuan Ko Chung-Wei Wu Jen-Yang Tang Ping-Ho Chen Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers The Scientific World Journal |
| title | Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers |
| title_full | Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers |
| title_fullStr | Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers |
| title_full_unstemmed | Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers |
| title_short | Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers |
| title_sort | cytochrome p450 metabolism of betel quid derived compounds implications for the development of prevention strategies for oral and pharyngeal cancers |
| url | http://dx.doi.org/10.1155/2013/618032 |
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