Heparan sulphate binding controls in vivo half-life of the HpARI protein family

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

The parasitic nematode Heligmosomoides polygyrus bakeri secretes the HpARI family, which bind to IL-33, either suppressing (HpARI1 and HpARI2) or enhancing (HpARI3) responses to the cytokine. We previously showed that HpARI2 also bound to DNA via its first complement control protein (CCP1) domain. H...

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Bibliographic Details
Main Authors: Florent Colomb, Abhishek Jamwal, Adefunke Ogunkanbi, Tania Frangova, Alice R Savage, Sarah Kelly, Gavin J Wright, Matthew K Higgins, Henry J McSorley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
Heligmosoides polygyrus bakeri
IL-33
heparan sulphate
Online Access:https://elifesciences.org/articles/99000
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