FOXP3 and cholesterol 7α-hydroxylase variants: unraveling genetic links to multiple sclerosis and neuromyelitis optica

FOXP3 and cholesterol 7α-hydroxylase variants: unraveling genetic links to multiple sclerosis and neuromyelitis optica

Abstract Background Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating disorders of the central nervous system. The FOXP3 (rs3761547) and CYP7A1 (rs3808607) polymorphisms together with vitamin D are thought to play a significant role in the pathophysiology of autoimm...

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Bibliographic Details
Main Authors: Aya Amir Nassef, Hebattalah Monir Mohammed Selim, Nevin Mohieldin Shalaby, Asmaa Ahmed Abdelrasool, Hend Hamed Tamim
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Subjects:
CYP7A1
FOXP3
MS
NMO
RFLP
Real-time PCR
Online Access:https://doi.org/10.1186/s41983-025-01002-2
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