Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy
Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to synaptic functions and increased the importance o...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824001596 |
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| author | Xiuhong Lu Bin Ji Gang Huang Hong Ding |
| author_facet | Xiuhong Lu Bin Ji Gang Huang Hong Ding |
| author_sort | Xiuhong Lu |
| collection | DOAJ |
| description | Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to synaptic functions and increased the importance of clinically available imaging for synaptic density and the development of synapse-targeted intervention. Synaptic density imaging with positron emission tomography (PET) tracer enables non-invasive detection of synaptic loss and hence investigates the association with other neuropathological events exemplified by disease-specific abnormal protein accumulation. Many studies have reviewed the progress of synaptic density imaging; however, to our knowledge, there is no article yet that summarizes the research progress of multimodal imaging of synaptic density tracers combined with other dementia biomarkers. Moreover, synaptic function intervention for dementia therapy has not yet been summarized. In this review, first we detail the progress of synaptic density imaging including tracer development and preclinical/clinical application, followed by a discussion of multimodal imaging of synaptic density tracers combined with classic dementia biomarkers in the clinical research stage. Finally, we briefly summarize the synapse-targeted drugs for dementia therapy. |
| format | Article |
| id | doaj-art-9400209e363541139fa81dc3ba11563f |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-9400209e363541139fa81dc3ba11563f2025-01-29T05:02:37ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-01516371Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapyXiuhong Lu0Bin Ji1Gang Huang2Hong Ding3Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai 201318, China; School of pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaDepartment of Radiopharmacy and Molecular Imaging, School of pharmacy, Fudan University, Shanghai 201203, ChinaShanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai 201318, China; Corresponding authors.Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai 201318, China; Corresponding authors.Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to synaptic functions and increased the importance of clinically available imaging for synaptic density and the development of synapse-targeted intervention. Synaptic density imaging with positron emission tomography (PET) tracer enables non-invasive detection of synaptic loss and hence investigates the association with other neuropathological events exemplified by disease-specific abnormal protein accumulation. Many studies have reviewed the progress of synaptic density imaging; however, to our knowledge, there is no article yet that summarizes the research progress of multimodal imaging of synaptic density tracers combined with other dementia biomarkers. Moreover, synaptic function intervention for dementia therapy has not yet been summarized. In this review, first we detail the progress of synaptic density imaging including tracer development and preclinical/clinical application, followed by a discussion of multimodal imaging of synaptic density tracers combined with classic dementia biomarkers in the clinical research stage. Finally, we briefly summarize the synapse-targeted drugs for dementia therapy.http://www.sciencedirect.com/science/article/pii/S2667325824001596Synaptic density imagingSynaptic vesicle protein 2ADementiaMultimodal imagingUCB-JPositron emission tomography |
| spellingShingle | Xiuhong Lu Bin Ji Gang Huang Hong Ding Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy Fundamental Research Synaptic density imaging Synaptic vesicle protein 2A Dementia Multimodal imaging UCB-J Positron emission tomography |
| title | Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy |
| title_full | Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy |
| title_fullStr | Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy |
| title_full_unstemmed | Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy |
| title_short | Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy |
| title_sort | advances in synaptic pet imaging and intervention with synapse targeted small molecular drugs for dementia diagnosis and therapy |
| topic | Synaptic density imaging Synaptic vesicle protein 2A Dementia Multimodal imaging UCB-J Positron emission tomography |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824001596 |
| work_keys_str_mv | AT xiuhonglu advancesinsynapticpetimagingandinterventionwithsynapsetargetedsmallmoleculardrugsfordementiadiagnosisandtherapy AT binji advancesinsynapticpetimagingandinterventionwithsynapsetargetedsmallmoleculardrugsfordementiadiagnosisandtherapy AT ganghuang advancesinsynapticpetimagingandinterventionwithsynapsetargetedsmallmoleculardrugsfordementiadiagnosisandtherapy AT hongding advancesinsynapticpetimagingandinterventionwithsynapsetargetedsmallmoleculardrugsfordementiadiagnosisandtherapy |