Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review
Abstract Introduction Mesenchymal stem cell (MSC)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines. Objective This review evaluates the clinical applications of MSC-conditioned media in improving scar...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04311-8 |
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| author | Sona Zare Alireza Jafarzadeh Solmaz Zare Amir Shamloo |
| author_facet | Sona Zare Alireza Jafarzadeh Solmaz Zare Amir Shamloo |
| author_sort | Sona Zare |
| collection | DOAJ |
| description | Abstract Introduction Mesenchymal stem cell (MSC)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines. Objective This review evaluates the clinical applications of MSC-conditioned media in improving scars, promoting wound healing, stimulating hair growth, and rejuvenating the skin. Materials and methods A thorough search of relevant databases was performed to identify studies meeting the inclusion criteria. From an initial pool of 75 articles, 16 studies published up to 2024 were selected based on their relevance, focus, and alignment with the research objectives. Results Among the 17 selected studies, 5 examined the role of conditioned media in skin rejuvenation, 3 investigated its effects on hair growth, 5 assessed its efficacy in scar treatment, 2 assessed its efficacy in Inflammatory Dermatologic Disease and 2 explored its role in wound healing. All studies reported favorable outcomes, demonstrating significant improvements in scars, hair regrowth, and skin rejuvenation with the application of conditioned media. Conclusion This review underscores the potential of MSC-derived conditioned media in dermatology. Several studies also highlighted its enhanced therapeutic effects when combined with adjunctive treatments, such as laser therapy and microneedling, showcasing improved outcomes in dermatological care. |
| format | Article |
| id | doaj-art-93ffe9e73eda4166b3c0a882b19fb4df |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-93ffe9e73eda4166b3c0a882b19fb4df2025-08-20T02:17:09ZengBMCStem Cell Research & Therapy1757-65122025-04-0116111710.1186/s13287-025-04311-8Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive reviewSona Zare0Alireza Jafarzadeh1Solmaz Zare2Amir Shamloo3Skin and Stem Cell Research Center, Tehran University of Medical SciencesDepartment of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical SciencesPersian Bio-Based Production (PBBP) Company, Sharif University of TechnologyStem Cell and Regenerative Medicine Institute, Sharif University of TechnologyAbstract Introduction Mesenchymal stem cell (MSC)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines. Objective This review evaluates the clinical applications of MSC-conditioned media in improving scars, promoting wound healing, stimulating hair growth, and rejuvenating the skin. Materials and methods A thorough search of relevant databases was performed to identify studies meeting the inclusion criteria. From an initial pool of 75 articles, 16 studies published up to 2024 were selected based on their relevance, focus, and alignment with the research objectives. Results Among the 17 selected studies, 5 examined the role of conditioned media in skin rejuvenation, 3 investigated its effects on hair growth, 5 assessed its efficacy in scar treatment, 2 assessed its efficacy in Inflammatory Dermatologic Disease and 2 explored its role in wound healing. All studies reported favorable outcomes, demonstrating significant improvements in scars, hair regrowth, and skin rejuvenation with the application of conditioned media. Conclusion This review underscores the potential of MSC-derived conditioned media in dermatology. Several studies also highlighted its enhanced therapeutic effects when combined with adjunctive treatments, such as laser therapy and microneedling, showcasing improved outcomes in dermatological care.https://doi.org/10.1186/s13287-025-04311-8Conditioned mediumMesenchymal stem cellsDermatologyHair growthRejuvenationScar |
| spellingShingle | Sona Zare Alireza Jafarzadeh Solmaz Zare Amir Shamloo Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review Stem Cell Research & Therapy Conditioned medium Mesenchymal stem cells Dermatology Hair growth Rejuvenation Scar |
| title | Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review |
| title_full | Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review |
| title_fullStr | Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review |
| title_full_unstemmed | Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review |
| title_short | Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review |
| title_sort | exploring the dermatological applications of human mesenchymal stem cell secretome a comprehensive review |
| topic | Conditioned medium Mesenchymal stem cells Dermatology Hair growth Rejuvenation Scar |
| url | https://doi.org/10.1186/s13287-025-04311-8 |
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