Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function
Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/129369 |
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| author | A. E. Berezin A. A. Kremzer |
| author_facet | A. E. Berezin A. A. Kremzer |
| author_sort | A. E. Berezin |
| collection | DOAJ |
| description | Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI) = 15.75–31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio , 95% CI = 1.20–1.82; ), osteopontin (, 95% CI = 1.12–1.25; ), osteoprotegerin (, 95% CI = 1.20–1.89; ), type 2 diabetes mellitus (, 95% CI = 1.20–1.72; ), and total cholesterol (, 95% CI = 1.10–1.22; ) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease. |
| format | Article |
| id | doaj-art-93ff71dd7c21446c8bbcec50ed09b4da |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-93ff71dd7c21446c8bbcec50ed09b4da2025-08-20T02:10:13ZengWileyCardiology Research and Practice2090-80162090-05972013-01-01201310.1155/2013/129369129369Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump FunctionA. E. Berezin0A. A. Kremzer1Internal Medicine Department, State Medical University, Zaporozhye 69035, UkraineClinical Pharmacology Department, State Medical University, Zaporozhye 69035, UkraineObjective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI) = 15.75–31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio , 95% CI = 1.20–1.82; ), osteopontin (, 95% CI = 1.12–1.25; ), osteoprotegerin (, 95% CI = 1.20–1.89; ), type 2 diabetes mellitus (, 95% CI = 1.20–1.72; ), and total cholesterol (, 95% CI = 1.10–1.22; ) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease.http://dx.doi.org/10.1155/2013/129369 |
| spellingShingle | A. E. Berezin A. A. Kremzer Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function Cardiology Research and Practice |
| title | Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function |
| title_full | Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function |
| title_fullStr | Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function |
| title_full_unstemmed | Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function |
| title_short | Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function |
| title_sort | serum uric acid as a marker of coronary calcification in patients with asymptomatic coronary artery disease with preserved left ventricular pump function |
| url | http://dx.doi.org/10.1155/2013/129369 |
| work_keys_str_mv | AT aeberezin serumuricacidasamarkerofcoronarycalcificationinpatientswithasymptomaticcoronaryarterydiseasewithpreservedleftventricularpumpfunction AT aakremzer serumuricacidasamarkerofcoronarycalcificationinpatientswithasymptomaticcoronaryarterydiseasewithpreservedleftventricularpumpfunction |