Mucin Overproduction in Chronic Inflammatory Lung Disease
Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by n...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2006/901417 |
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| _version_ | 1849403225613008896 |
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| author | Hans-Peter Hauber Susan C Foley Qutayba Hamid |
| author_facet | Hans-Peter Hauber Susan C Foley Qutayba Hamid |
| author_sort | Hans-Peter Hauber |
| collection | DOAJ |
| description | Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed. |
| format | Article |
| id | doaj-art-93fcb393478e43f2b09faadc16665bbd |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-93fcb393478e43f2b09faadc16665bbd2025-08-20T03:37:19ZengWileyCanadian Respiratory Journal1198-22412006-01-0113632733510.1155/2006/901417Mucin Overproduction in Chronic Inflammatory Lung DiseaseHans-Peter Hauber0Susan C Foley1Qutayba Hamid2Meakins-Christie Laboratories, McGill University, Montreal, Quebec, CanadaMeakins-Christie Laboratories, McGill University, Montreal, Quebec, CanadaMeakins-Christie Laboratories, McGill University, Montreal, Quebec, CanadaMucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.http://dx.doi.org/10.1155/2006/901417 |
| spellingShingle | Hans-Peter Hauber Susan C Foley Qutayba Hamid Mucin Overproduction in Chronic Inflammatory Lung Disease Canadian Respiratory Journal |
| title | Mucin Overproduction in Chronic Inflammatory Lung Disease |
| title_full | Mucin Overproduction in Chronic Inflammatory Lung Disease |
| title_fullStr | Mucin Overproduction in Chronic Inflammatory Lung Disease |
| title_full_unstemmed | Mucin Overproduction in Chronic Inflammatory Lung Disease |
| title_short | Mucin Overproduction in Chronic Inflammatory Lung Disease |
| title_sort | mucin overproduction in chronic inflammatory lung disease |
| url | http://dx.doi.org/10.1155/2006/901417 |
| work_keys_str_mv | AT hanspeterhauber mucinoverproductioninchronicinflammatorylungdisease AT susancfoley mucinoverproductioninchronicinflammatorylungdisease AT qutaybahamid mucinoverproductioninchronicinflammatorylungdisease |