Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance
Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS). The groundbreaking application of multi-omics integration technologies has unveiled a novel role for lactate:...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1566921/full |
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| author | Jiaxin Tian Tongyu Zhang Ruidan Zhang Sijia Hao Jingyu Dong Yiyan Chen Jinpeng Zhou Yang Tian |
| author_facet | Jiaxin Tian Tongyu Zhang Ruidan Zhang Sijia Hao Jingyu Dong Yiyan Chen Jinpeng Zhou Yang Tian |
| author_sort | Jiaxin Tian |
| collection | DOAJ |
| description | Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS). The groundbreaking application of multi-omics integration technologies has unveiled a novel role for lactate: lactylation, a unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function and gene expression, profoundly influencing the progression of various diseases. The lactylation process is meticulously regulated by a variety of key enzymes and metabolic pathways, forming a dynamic and intricate modification network. In this review, we summarize the key enzymes involved in lactylation, specifically “Writers,” “Erasers,” and “Readers.” Furthermore, we systematically categorize lactylation observed in various cell types within the CNS and investigate its multifaceted roles in pathological processes, including neurodegenerative diseases, brain tumors, and brain injuries. By consolidating the latest research findings in this field, our review aims to highlight the significance of these discoveries for future research and explore their potential for translational applications. |
| format | Article |
| id | doaj-art-93fb3e976a9c4e048f7c41f83fd47e77 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-93fb3e976a9c4e048f7c41f83fd47e772025-08-20T02:48:46ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15669211566921Lactylation in CNS disorders: mechanisms, cellular function, and disease relevanceJiaxin Tian0Tongyu Zhang1Ruidan Zhang2Sijia Hao3Jingyu Dong4Yiyan Chen5Jinpeng Zhou6Yang Tian7Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Obstetrics, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi Province, ChinaDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, ChinaLactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS). The groundbreaking application of multi-omics integration technologies has unveiled a novel role for lactate: lactylation, a unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function and gene expression, profoundly influencing the progression of various diseases. The lactylation process is meticulously regulated by a variety of key enzymes and metabolic pathways, forming a dynamic and intricate modification network. In this review, we summarize the key enzymes involved in lactylation, specifically “Writers,” “Erasers,” and “Readers.” Furthermore, we systematically categorize lactylation observed in various cell types within the CNS and investigate its multifaceted roles in pathological processes, including neurodegenerative diseases, brain tumors, and brain injuries. By consolidating the latest research findings in this field, our review aims to highlight the significance of these discoveries for future research and explore their potential for translational applications.https://www.frontiersin.org/articles/10.3389/fcell.2025.1566921/fulllactylationCNS disordersmechanismcellular functiondisease pathology |
| spellingShingle | Jiaxin Tian Tongyu Zhang Ruidan Zhang Sijia Hao Jingyu Dong Yiyan Chen Jinpeng Zhou Yang Tian Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance Frontiers in Cell and Developmental Biology lactylation CNS disorders mechanism cellular function disease pathology |
| title | Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance |
| title_full | Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance |
| title_fullStr | Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance |
| title_full_unstemmed | Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance |
| title_short | Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance |
| title_sort | lactylation in cns disorders mechanisms cellular function and disease relevance |
| topic | lactylation CNS disorders mechanism cellular function disease pathology |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1566921/full |
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