High-resolution melt curve analysis: An approach for variant detection in the TPO gene of congenital hypothyroid patients in Bangladesh.

High-resolution melt curve analysis: An approach for variant detection in the TPO gene of congenital hypothyroid patients in Bangladesh.

TPO (Thyroid Peroxidase) is known to be one of the major genes involved in congenital hypothyroid patients with thyroid dyshormonogenesis. The present study aims to validate high-resolution melting (HRM) curve analysis as a substitute method for Sanger sequencing, focusing on the frequently observed...

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Main Authors: Mst Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Nusrat Jahan Antora, Suprovath Kumar Sarker, Nusrat Sultana, Abu A Sajib, Abul B M M K Islam, Hurjahan Banu, M A Hasanat, Kohinoor Jahan Shyamaly, Suraiya Begum, Tasnia Kawsar Konika, Shahinur Haque, Mizanul Hasan, Sadia Sultana, Taufiqur Rahman Bhuiyan, Kaiissar Mannoor, Firdausi Qadri, Sharif Akhteruzzaman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293570&type=printable
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