Role of Myeloid-Derived Suppressor Cells (MDSCs), Specifically Monocyte-Derived MDSCs, in Type 2 Diabetes-Related Diabetic Retinopathy
Xiaoli Xiang,1,2 Zhicheng Zhang,3 Wenxuan Xu,3 Zhengru Huang,2 Ji Zhang1 1Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Ophthalmology, Affiliated Changshu Hospital of Nantong University, Changshu, People’s Republ...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/role-of-myeloid-derived-suppressor-cells-mdscs-specifically-monocyte-d-peer-reviewed-fulltext-article-DMSO |
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| Summary: | Xiaoli Xiang,1,2 Zhicheng Zhang,3 Wenxuan Xu,3 Zhengru Huang,2 Ji Zhang1 1Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Ophthalmology, Affiliated Changshu Hospital of Nantong University, Changshu, People’s Republic of China; 3Department of Key Laboratory, Affiliated Changshu Hospital of Nantong University, Changshu, People’s Republic of ChinaCorrespondence: Zhengru Huang, Department of Ophthalmology, Affiliated Changshu Hospital of Nantong University, No. 68 Haiyu Nan Road, Changshu, Jiangsu, People’s Republic of China, Email hzhengru@163.com Ji Zhang, Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, Jiangsu, People’s Republic of China, Email jizhang@suda.edu.cnPurpose: The role of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of diabetic retinopathy (DR) in patients with type 2 diabetes remains unclear. Thus, we aimed to determine whether these cells are involved in the pathogenesis of DR.Patients and Methods: Blood samples were collected from 42 patients with type 2 diabetes and DR and 20 age- and sex-matched healthy volunteers. MDSCs, including monocyte-derived (M-MDSCs) and granulocyte-derived (G-MDSCs) subpopulations, were detected via flow cytometry.Results: The difference in the percentage of peripheral blood M-MDSCs among the three groups was statistically significant. Significant differences were observed between proliferative DR (PDR), nonproliferative DR (NPDR), and healthy controls in terms of M-MDSC percentage. No significant differences were observed between the NPDR and healthy control groups. The percentage of peripheral blood G-MDSCs did not significantly differ among the three groups. Moreover, the proportion of M-MDSCs in the peripheral blood of patients positively correlated with fasting blood glucose and glycosylated hemoglobin levels.Conclusion: The percentage of M-MDSCs in peripheral blood was significantly higher in the PDR group and positively correlated with fasting blood glucose and glycosylated hemoglobin levels. Our findings suggest that M-MDSCs, particularly in the proliferative stage of DR, may serve as potential biomarkers for disease progression and offer insights into future clinical or therapeutic strategies.Keywords: peripheral blood, fasting blood glucose, glycosylated hemoglobin |
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| ISSN: | 1178-7007 |