The Role of Cardiopulmonary Exercise Test in IPF Prognosis
Background. In IPF, defects in lung mechanics and gas exchange manifest with exercise limitation due to dyspnea, the most prominent and disabling symptom. Aim. To evaluate the role of exercise testing through the 6MWT (6-minute walk test) and CPET (cardiopulmonary exercise testing) in the survival o...
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Wiley
2013-01-01
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Series: | Pulmonary Medicine |
Online Access: | http://dx.doi.org/10.1155/2013/514817 |
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author | Christina Triantafillidou Effrosyni Manali Panagiotis Lyberopoulos Likourgos Kolilekas Konstantinos Kagouridis Sotirios Gyftopoulos Konstantinos Vougas Anastasia Kotanidou Manos Alchanatis Anna Karakatsani Spyros A. Papiris |
author_facet | Christina Triantafillidou Effrosyni Manali Panagiotis Lyberopoulos Likourgos Kolilekas Konstantinos Kagouridis Sotirios Gyftopoulos Konstantinos Vougas Anastasia Kotanidou Manos Alchanatis Anna Karakatsani Spyros A. Papiris |
author_sort | Christina Triantafillidou |
collection | DOAJ |
description | Background. In IPF, defects in lung mechanics and gas exchange manifest with exercise limitation due to dyspnea, the most prominent and disabling symptom. Aim. To evaluate the role of exercise testing through the 6MWT (6-minute walk test) and CPET (cardiopulmonary exercise testing) in the survival of patients with IPF. Methods. This is a prospective, observational study evaluating in 25 patients the relationship between exercise variables through both the 6MWT and CPET and survival. Results. By the end of the observational period 17 patients were alive (33% mortality). Observation ranged from 9 to 64 months. VE/VCO2 slope (slope of relation between minute ventilation and CO2 production), VO2 peak/kg (peak oxygen consumption/kg), VE/VCO2 ratio at anaerobic threshold, 6MWT distance, desaturation, and DLCO% were significant predictors of survival while VE/VCO2 slope and VO2 peak/kg had the strongest correlation with outcome. The optimal model for mortality risk estimation was VO2 peak/kg + DLCO% combined. Furthermore, VE/VCO2 slope and VO2 peak/kg were correlated with distance and desaturation during the 6MWT. Conclusion. The integration of oxygen consumption and diffusing capacity proved to be a reliable predictor of survival because both variables reflect major underlying physiologic determinants of exercise limitation. |
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id | doaj-art-93ec1bf80854456b8b2e3fd9ca0d7c78 |
institution | Kabale University |
issn | 2090-1836 2090-1844 |
language | English |
publishDate | 2013-01-01 |
publisher | Wiley |
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series | Pulmonary Medicine |
spelling | doaj-art-93ec1bf80854456b8b2e3fd9ca0d7c782025-02-03T05:44:58ZengWileyPulmonary Medicine2090-18362090-18442013-01-01201310.1155/2013/514817514817The Role of Cardiopulmonary Exercise Test in IPF PrognosisChristina Triantafillidou0Effrosyni Manali1Panagiotis Lyberopoulos2Likourgos Kolilekas3Konstantinos Kagouridis4Sotirios Gyftopoulos5Konstantinos Vougas6Anastasia Kotanidou7Manos Alchanatis8Anna Karakatsani9Spyros A. Papiris102nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, GreeceGenomics and Proteomics Research Units, Center of Basic Research II, Biomedical Research Foundation, Academy of Athens, 11527 Athens, GreeceApplied Biochemical Research and Training Laboratory “Marianthi Simou”, Thorax Foundation and Department of Critical Care and Pulmonary Services, National and Kapodistrian University of Athens, “Evangelismos” Hospital, 3 Ploutarchou Street, 10675 Athens, Greece1st Pulmonary Department, “Sotiria” Chest Diseases Hospital, Athens Medical School, National and Kapodistrian University of Athens, 152 Mesogion Street, 11527 Athens, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, Greece2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Haidari, GreeceBackground. In IPF, defects in lung mechanics and gas exchange manifest with exercise limitation due to dyspnea, the most prominent and disabling symptom. Aim. To evaluate the role of exercise testing through the 6MWT (6-minute walk test) and CPET (cardiopulmonary exercise testing) in the survival of patients with IPF. Methods. This is a prospective, observational study evaluating in 25 patients the relationship between exercise variables through both the 6MWT and CPET and survival. Results. By the end of the observational period 17 patients were alive (33% mortality). Observation ranged from 9 to 64 months. VE/VCO2 slope (slope of relation between minute ventilation and CO2 production), VO2 peak/kg (peak oxygen consumption/kg), VE/VCO2 ratio at anaerobic threshold, 6MWT distance, desaturation, and DLCO% were significant predictors of survival while VE/VCO2 slope and VO2 peak/kg had the strongest correlation with outcome. The optimal model for mortality risk estimation was VO2 peak/kg + DLCO% combined. Furthermore, VE/VCO2 slope and VO2 peak/kg were correlated with distance and desaturation during the 6MWT. Conclusion. The integration of oxygen consumption and diffusing capacity proved to be a reliable predictor of survival because both variables reflect major underlying physiologic determinants of exercise limitation.http://dx.doi.org/10.1155/2013/514817 |
spellingShingle | Christina Triantafillidou Effrosyni Manali Panagiotis Lyberopoulos Likourgos Kolilekas Konstantinos Kagouridis Sotirios Gyftopoulos Konstantinos Vougas Anastasia Kotanidou Manos Alchanatis Anna Karakatsani Spyros A. Papiris The Role of Cardiopulmonary Exercise Test in IPF Prognosis Pulmonary Medicine |
title | The Role of Cardiopulmonary Exercise Test in IPF Prognosis |
title_full | The Role of Cardiopulmonary Exercise Test in IPF Prognosis |
title_fullStr | The Role of Cardiopulmonary Exercise Test in IPF Prognosis |
title_full_unstemmed | The Role of Cardiopulmonary Exercise Test in IPF Prognosis |
title_short | The Role of Cardiopulmonary Exercise Test in IPF Prognosis |
title_sort | role of cardiopulmonary exercise test in ipf prognosis |
url | http://dx.doi.org/10.1155/2013/514817 |
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