Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review
(1) Objective: Cardiovascular diseases (CVD) are one of the main entities responsible for the progressive increase in morbidity and mortality worldwide. Some of the biomarkers involved in these processes are matrix metalloproteases (MMPs) and disintegrants and metalloproteases (ADAMS), produced by m...
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| Format: | Article |
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2025-05-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/15/2/14 |
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| author | Laura Manuela Olarte Bermúdez Camila Karduss Preciado Julián Manuel Espitia Ángel Ana María Santos Granados Julio Cesar Martínez Lozano Carlos Alberto Pacheco Cuentas Diana Marcela Díaz Quijano |
| author_facet | Laura Manuela Olarte Bermúdez Camila Karduss Preciado Julián Manuel Espitia Ángel Ana María Santos Granados Julio Cesar Martínez Lozano Carlos Alberto Pacheco Cuentas Diana Marcela Díaz Quijano |
| author_sort | Laura Manuela Olarte Bermúdez |
| collection | DOAJ |
| description | (1) Objective: Cardiovascular diseases (CVD) are one of the main entities responsible for the progressive increase in morbidity and mortality worldwide. Some of the biomarkers involved in these processes are matrix metalloproteases (MMPs) and disintegrants and metalloproteases (ADAMS), produced by multiple tissues and whose main function is the excessive degradation of the extracellular matrix (ECM). The aim of this study is to describe the existing literature on the role of MMP in the pathophysiology of CVD and its usefulness in clinical practice for the diagnostic and therapeutic approach. (2) Methods: A systematic exploratory review of the literature was carried out according to the guidelines of the Joanna Briggs Institute. The information was collected from the PubMed/Medline and Embase databases, using the search strategy “cardiovascular disease” AND “Metalloprotease”. (3) Results: Thirty eight papers that mainly mention 17 types of MMPs were included. Pathologies such as atherosclerosis, coagulation diseases, atrial fibrillation, ischemic heart disease, heart failure, hypertension, dyslipidemias, congenital cyanotic heart disease and Takotsubo cardiomyopathy were identified. (4) Conclusions: The stimulation or inhibition of these biomolecules could generate positive and/or negative effects, which impact the development and prognosis of the disease. Furthermore, they can be potential biomarkers for new diagnostic and even therapeutic approaches in the future. |
| format | Article |
| id | doaj-art-93e91aebc8764023992fcd723e175ad1 |
| institution | Kabale University |
| issn | 2035-8253 2035-8148 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj-art-93e91aebc8764023992fcd723e175ad12025-08-20T03:27:28ZengMDPI AGCardiogenetics2035-82532035-81482025-05-011521410.3390/cardiogenetics15020014Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping ReviewLaura Manuela Olarte Bermúdez0Camila Karduss Preciado1Julián Manuel Espitia Ángel2Ana María Santos Granados3Julio Cesar Martínez Lozano4Carlos Alberto Pacheco Cuentas5Diana Marcela Díaz Quijano6Fundación Santa Fe de Bogotá, Bogotá 110111, Cundinamarca, ColombiaFaculty of Medicine, University of La Sabana, Chía 250007, Cundinamarca, ColombiaFaculty of Medicine, University of La Sabana, Chía 250007, Cundinamarca, ColombiaSpondyloarthropathies Research Group, School of Medicine, University of La Sabana, Chía 250007, Cundinamarca, ColombiaHuman Genetics Research Group, School of Medicine, University of La Sabana, Chía 250007, Cundinamarca, ColombiaCardiology Group at Clínica Universidad de La Sabana, School of Medicine, University of La Sabana, Chía 250007, Cundinamarca, ColombiaHealth Research Group, School of Medicine, University of La Sabana, Chía 250007, Cundinamarca, Colombia(1) Objective: Cardiovascular diseases (CVD) are one of the main entities responsible for the progressive increase in morbidity and mortality worldwide. Some of the biomarkers involved in these processes are matrix metalloproteases (MMPs) and disintegrants and metalloproteases (ADAMS), produced by multiple tissues and whose main function is the excessive degradation of the extracellular matrix (ECM). The aim of this study is to describe the existing literature on the role of MMP in the pathophysiology of CVD and its usefulness in clinical practice for the diagnostic and therapeutic approach. (2) Methods: A systematic exploratory review of the literature was carried out according to the guidelines of the Joanna Briggs Institute. The information was collected from the PubMed/Medline and Embase databases, using the search strategy “cardiovascular disease” AND “Metalloprotease”. (3) Results: Thirty eight papers that mainly mention 17 types of MMPs were included. Pathologies such as atherosclerosis, coagulation diseases, atrial fibrillation, ischemic heart disease, heart failure, hypertension, dyslipidemias, congenital cyanotic heart disease and Takotsubo cardiomyopathy were identified. (4) Conclusions: The stimulation or inhibition of these biomolecules could generate positive and/or negative effects, which impact the development and prognosis of the disease. Furthermore, they can be potential biomarkers for new diagnostic and even therapeutic approaches in the future.https://www.mdpi.com/2035-8148/15/2/14metalloproteasescardiovascular diseasedisintegrants and metalloproteases |
| spellingShingle | Laura Manuela Olarte Bermúdez Camila Karduss Preciado Julián Manuel Espitia Ángel Ana María Santos Granados Julio Cesar Martínez Lozano Carlos Alberto Pacheco Cuentas Diana Marcela Díaz Quijano Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review Cardiogenetics metalloproteases cardiovascular disease disintegrants and metalloproteases |
| title | Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review |
| title_full | Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review |
| title_fullStr | Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review |
| title_full_unstemmed | Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review |
| title_short | Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review |
| title_sort | pathophysiological bases and clinical uses of metalloproteases in cardiovascular disease a scoping review |
| topic | metalloproteases cardiovascular disease disintegrants and metalloproteases |
| url | https://www.mdpi.com/2035-8148/15/2/14 |
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