Chemical proteomics enhances the understanding of 2AA stress in Salmonella enterica
ABSTRACT Pyridoxal 5′-phosphate (PLP) is an essential cofactor for enzymes that catalyze diverse reactions in central metabolism. 2-Aminoacrylate (2AA) is a reactive enamine and an obligate catalytic intermediate in some PLP-mediated reactions. In the absence of the enamine/imine deaminase RidA, Sal...
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| Main Authors: | Dominik Schum, Michaela K. Fiedler, Wangchen Shen, Stephan A. Sieber, Diana M. Downs |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2025-06-01
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| Series: | mSystems |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/msystems.00540-25 |
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