Chemical proteomics enhances the understanding of 2AA stress in Salmonella enterica

ABSTRACT Pyridoxal 5′-phosphate (PLP) is an essential cofactor for enzymes that catalyze diverse reactions in central metabolism. 2-Aminoacrylate (2AA) is a reactive enamine and an obligate catalytic intermediate in some PLP-mediated reactions. In the absence of the enamine/imine deaminase RidA, Sal...

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Bibliographic Details
Main Authors: Dominik Schum, Michaela K. Fiedler, Wangchen Shen, Stephan A. Sieber, Diana M. Downs
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mSystems
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Online Access:https://journals.asm.org/doi/10.1128/msystems.00540-25
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