m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization
Atherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes of macrophages have the polarization capability, each influen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607932/full |
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| author | Xiaying Li Xiaying Li Hengkai Zhang Yan Zhou Lei Zhang Ye Huang Ye Huang |
| author_facet | Xiaying Li Xiaying Li Hengkai Zhang Yan Zhou Lei Zhang Ye Huang Ye Huang |
| author_sort | Xiaying Li |
| collection | DOAJ |
| description | Atherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes of macrophages have the polarization capability, each influencing the inflammatory state through the secretion of distinct cytokines. N6-methyladenosine (m6A) modification, the most prevalent internal chemical modification of RNA, significantly impacts various biological processes, including RNA transcription and protein expression. m6A modification acts as a critical determinant in macrophage polarization, with its molecular mechanisms intricately linked to the progression of atherosclerosis. This review aims to elucidate how different macrophage polarization phenotypes influence the progression of atherosclerosis while also exploring the significance of m6A modifications in this pathological context, thereby providing a theoretical foundation for identifying novel diagnostic and therapeutic targets for atherosclerosis. |
| format | Article |
| id | doaj-art-93e08f57f24a42f5bfacd5e20beeaf32 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-93e08f57f24a42f5bfacd5e20beeaf322025-08-20T02:07:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16079321607932m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarizationXiaying Li0Xiaying Li1Hengkai Zhang2Yan Zhou3Lei Zhang4Ye Huang5Ye Huang6Graduate School, Beijing University of Chinese Medicine, Beijing, ChinaEmergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaEmergency Department, Shanxi Traditional Chinese Medical Hospital, Shanxi, ChinaEmergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaEmergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaEmergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaAtherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes of macrophages have the polarization capability, each influencing the inflammatory state through the secretion of distinct cytokines. N6-methyladenosine (m6A) modification, the most prevalent internal chemical modification of RNA, significantly impacts various biological processes, including RNA transcription and protein expression. m6A modification acts as a critical determinant in macrophage polarization, with its molecular mechanisms intricately linked to the progression of atherosclerosis. This review aims to elucidate how different macrophage polarization phenotypes influence the progression of atherosclerosis while also exploring the significance of m6A modifications in this pathological context, thereby providing a theoretical foundation for identifying novel diagnostic and therapeutic targets for atherosclerosis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607932/fullmacrophage polarizationcytokinesatherosclerosisN 6 -methyladenosine modificationinflammatory |
| spellingShingle | Xiaying Li Xiaying Li Hengkai Zhang Yan Zhou Lei Zhang Ye Huang Ye Huang m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization Frontiers in Immunology macrophage polarization cytokines atherosclerosis N 6 -methyladenosine modification inflammatory |
| title | m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization |
| title_full | m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization |
| title_fullStr | m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization |
| title_full_unstemmed | m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization |
| title_short | m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization |
| title_sort | m6a modification a novel mechanism that regulates atherosclerosis via macrophage polarization |
| topic | macrophage polarization cytokines atherosclerosis N 6 -methyladenosine modification inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607932/full |
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