Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint
Aims: To compare the effectiveness between intra-articular injection (IAI) of autologous platelet-rich plasma (PRP) vs hyaluronic acid (HA) vs activated PRP in primary osteoarthritis (OA) of the knee grades 1 and 2, in terms of pre- and postinjection functional outcome by the Western Ontario and McM...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2024-01-01
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| Series: | Journal of Orthopedics and Joint Surgery |
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| Online Access: | https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1134 |
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| author | Vidya S Konana Harish S Yallapura Sriharsha Bettaswamy Srinivas P Sivaram Darshan G Thimmegowda |
| author_facet | Vidya S Konana Harish S Yallapura Sriharsha Bettaswamy Srinivas P Sivaram Darshan G Thimmegowda |
| author_sort | Vidya S Konana |
| collection | DOAJ |
| description | Aims: To compare the effectiveness between intra-articular injection (IAI) of autologous platelet-rich plasma (PRP) vs hyaluronic acid (HA) vs activated PRP in primary osteoarthritis (OA) of the knee grades 1 and 2, in terms of pre- and postinjection functional outcome by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale, and pre- and postinjection pain by visual analog scale (VAS).
Materials and methods: The patients were divided into three groups based on the treatment they received. Group I received an HA injection of 25 mg, group II received an autologous PRP injection, and group III received an activated autologous PRP injection. The patients were evaluated primarily with WOMAC scale improvement and secondarily by VAS at the time of getting the injection (0), at the end of 1 month, and at the end of 3 months.
Results: A total of 71 candidates were finally included in the study. Patients' mean age of HA, PRP, and activated PRP was 54.5 ± 6.79, 55.47 ± 6.31, and 55.73 ± 7.33, respectively. In the HA group, the total WOMAC index decreased from 42.95 ± 3.49 to 21.29 ± 21.29, from 41.52 ± 4.17 to 18.91 ± 1.4 in the PRP group, and from 43.82 ± 4.67 to 18.91 ± 2.44 in the activated PRP group after 3 months (<i>p</i>-value is significant). Regarding the VAS scale, it significantly decreased after 3 months in the activated PRP group compared to others.
Conclusion: The data revealed significant improvements in the WOMAC scale and VAS in all the groups at the 1- and 3-month follow-up visits. When comparing the change of WOMAC Scale and VAS at 1- and 3-month follow-ups, significant differences were found between the PRP and HA group and the activated PRP group, with activated PRP showing better outcomes compared to others. |
| format | Article |
| id | doaj-art-93e0684bf0b7447089161c9682782e43 |
| institution | Kabale University |
| issn | 2582-7863 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Journal of Orthopedics and Joint Surgery |
| spelling | doaj-art-93e0684bf0b7447089161c9682782e432025-02-07T11:17:47ZengJaypee Brothers Medical PublisherJournal of Orthopedics and Joint Surgery2582-78632024-01-0161273410.5005/jojs-10079-11345Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee JointVidya S Konana0Harish S Yallapura1Sriharsha Bettaswamy2https://orcid.org/0000-0002-3857-745XSrinivas P Sivaram3https://orcid.org/0000-0001-5572-053XDarshan G Thimmegowda4https://orcid.org/0009-0005-8856-4058Department of Orthopedics, ESIC Medical College & PGIMSR, Bengaluru, Karnataka, IndiaDepartment of Orthopedics, ESIC Medical College & PGIMSR, Bengaluru, Karnataka, IndiaDepartment of Orthopedics, ESIC Medical College & PGIMSR, Bengaluru, Karnataka, IndiaSrinivas P Sivaram, Department of Orthopedics, ESIC Medical College & PGIMSR, Bengaluru, Karnataka, India, Phone: +91 8861426612Department of Orthopedics, ESIC Medical College & PGIMSR, Bengaluru, Karnataka, IndiaAims: To compare the effectiveness between intra-articular injection (IAI) of autologous platelet-rich plasma (PRP) vs hyaluronic acid (HA) vs activated PRP in primary osteoarthritis (OA) of the knee grades 1 and 2, in terms of pre- and postinjection functional outcome by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scale, and pre- and postinjection pain by visual analog scale (VAS). Materials and methods: The patients were divided into three groups based on the treatment they received. Group I received an HA injection of 25 mg, group II received an autologous PRP injection, and group III received an activated autologous PRP injection. The patients were evaluated primarily with WOMAC scale improvement and secondarily by VAS at the time of getting the injection (0), at the end of 1 month, and at the end of 3 months. Results: A total of 71 candidates were finally included in the study. Patients' mean age of HA, PRP, and activated PRP was 54.5 ± 6.79, 55.47 ± 6.31, and 55.73 ± 7.33, respectively. In the HA group, the total WOMAC index decreased from 42.95 ± 3.49 to 21.29 ± 21.29, from 41.52 ± 4.17 to 18.91 ± 1.4 in the PRP group, and from 43.82 ± 4.67 to 18.91 ± 2.44 in the activated PRP group after 3 months (<i>p</i>-value is significant). Regarding the VAS scale, it significantly decreased after 3 months in the activated PRP group compared to others. Conclusion: The data revealed significant improvements in the WOMAC scale and VAS in all the groups at the 1- and 3-month follow-up visits. When comparing the change of WOMAC Scale and VAS at 1- and 3-month follow-ups, significant differences were found between the PRP and HA group and the activated PRP group, with activated PRP showing better outcomes compared to others.https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1134hyaluronic acidintra-articular injectionskneeosteoarthritisplatelet-rich plasma-derived growth factorplatelet-rich plasma |
| spellingShingle | Vidya S Konana Harish S Yallapura Sriharsha Bettaswamy Srinivas P Sivaram Darshan G Thimmegowda Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint Journal of Orthopedics and Joint Surgery hyaluronic acid intra-articular injections knee osteoarthritis platelet-rich plasma-derived growth factor platelet-rich plasma |
| title | Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint |
| title_full | Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint |
| title_fullStr | Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint |
| title_full_unstemmed | Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint |
| title_short | Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee Joint |
| title_sort | comparing the effectiveness of intra articular injection with autologous platelet rich plasma vs hyaluronic acid vs platelet derived growth factors in early osteoarthritis of knee joint |
| topic | hyaluronic acid intra-articular injections knee osteoarthritis platelet-rich plasma-derived growth factor platelet-rich plasma |
| url | https://www.jojs.in/doi/JOJS/pdf/10.5005/jojs-10079-1134 |
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