ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION
Aim. To access the role of endothelial adhesive dysfunction in the development of atrial fibrillation (AF) in patients with ischemic heart disease (IHD) complicated by chronic heart failure (CHF).Material and methods. 111 patients with CHF class I–IV due to myocardial ischemia were included in the s...
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/39 |
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| author | A. N. Zakirova E. R. Abdukova N. E. Zakirova |
| author_facet | A. N. Zakirova E. R. Abdukova N. E. Zakirova |
| author_sort | A. N. Zakirova |
| collection | DOAJ |
| description | Aim. To access the role of endothelial adhesive dysfunction in the development of atrial fibrillation (AF) in patients with ischemic heart disease (IHD) complicated by chronic heart failure (CHF).Material and methods. 111 patients with CHF class I–IV due to myocardial ischemia were included in the study. All participants were divided into four groups according to the presence of AF and CHF class. The control group consisted of 25 healthy individuals. Endothelial adhesive function was assessed by levels of soluble intercellular adhesive molecules sVCAM-1 and sE-selectin.Results. The sVCAM-1 level in patients with CHF class III–IV with AF was significantly higher than this in control group and patients with CHF class I–II regardless of AF occurrence, as well as higher than this in patients with CHF class III–IV without AF (65%, 56.1%, 36.3% and 13.9%, respectively, p<0.05). Direct correlations between sVCAM-1 level and the left atrium volume index (LAVI) (r=0.52; p<0.05) and between sE-selectin level and LAVI (r=0.48; p<0.05) were revealed.Conclusion. Endothelial adhesive dysfunction associates with AF existence and the severity of CHF. |
| format | Article |
| id | doaj-art-93d6d58e62f447d394c459667461cf87 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-93d6d58e62f447d394c459667461cf872025-08-23T10:00:15ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0191353910.20996/1819-6446-2013-9-1-35-3939ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATIONA. N. Zakirova0E. R. Abdukova1N. E. Zakirova2Bashkir State Medical University, UfaBashkir State Medical University, UfaBashkir State Medical University, UfaAim. To access the role of endothelial adhesive dysfunction in the development of atrial fibrillation (AF) in patients with ischemic heart disease (IHD) complicated by chronic heart failure (CHF).Material and methods. 111 patients with CHF class I–IV due to myocardial ischemia were included in the study. All participants were divided into four groups according to the presence of AF and CHF class. The control group consisted of 25 healthy individuals. Endothelial adhesive function was assessed by levels of soluble intercellular adhesive molecules sVCAM-1 and sE-selectin.Results. The sVCAM-1 level in patients with CHF class III–IV with AF was significantly higher than this in control group and patients with CHF class I–II regardless of AF occurrence, as well as higher than this in patients with CHF class III–IV without AF (65%, 56.1%, 36.3% and 13.9%, respectively, p<0.05). Direct correlations between sVCAM-1 level and the left atrium volume index (LAVI) (r=0.52; p<0.05) and between sE-selectin level and LAVI (r=0.48; p<0.05) were revealed.Conclusion. Endothelial adhesive dysfunction associates with AF existence and the severity of CHF.https://www.rpcardio.online/jour/article/view/39ischemic heart diseasechronic heart failureatrial fibrillationadhesive molecules |
| spellingShingle | A. N. Zakirova E. R. Abdukova N. E. Zakirova ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION Рациональная фармакотерапия в кардиологии ischemic heart disease chronic heart failure atrial fibrillation adhesive molecules |
| title | ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION |
| title_full | ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION |
| title_fullStr | ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION |
| title_full_unstemmed | ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION |
| title_short | ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION |
| title_sort | endothelial adhesive function in patients with ischemic heart disease complicated by chronic heart failure and atrial fibrillation |
| topic | ischemic heart disease chronic heart failure atrial fibrillation adhesive molecules |
| url | https://www.rpcardio.online/jour/article/view/39 |
| work_keys_str_mv | AT anzakirova endothelialadhesivefunctioninpatientswithischemicheartdiseasecomplicatedbychronicheartfailureandatrialfibrillation AT erabdukova endothelialadhesivefunctioninpatientswithischemicheartdiseasecomplicatedbychronicheartfailureandatrialfibrillation AT nezakirova endothelialadhesivefunctioninpatientswithischemicheartdiseasecomplicatedbychronicheartfailureandatrialfibrillation |