Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to im...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/2756459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565596054618112 |
|---|---|
| author | Lei Wang Liping Liang Shuzhen Shi Chao Wang |
| author_facet | Lei Wang Liping Liang Shuzhen Shi Chao Wang |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment. |
| format | Article |
| id | doaj-art-93d4f90f7f594847b88c0fdb3cdcc6a7 |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-93d4f90f7f594847b88c0fdb3cdcc6a72025-02-03T01:07:16ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/2756459Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver CancerLei Wang0Liping Liang1Shuzhen Shi2Chao Wang3Department of PharmacyDepartment of PharmacyDepartment of PharmacyPharmacy Department of Qingdao Chest HospitalDoxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment.http://dx.doi.org/10.1155/2022/2756459 |
| spellingShingle | Lei Wang Liping Liang Shuzhen Shi Chao Wang Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer Applied Bionics and Biomechanics |
| title | Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer |
| title_full | Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer |
| title_fullStr | Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer |
| title_full_unstemmed | Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer |
| title_short | Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer |
| title_sort | study on the application of doxorubicin loaded magnetic nanodrugs in targeted therapy of liver cancer |
| url | http://dx.doi.org/10.1155/2022/2756459 |
| work_keys_str_mv | AT leiwang studyontheapplicationofdoxorubicinloadedmagneticnanodrugsintargetedtherapyoflivercancer AT lipingliang studyontheapplicationofdoxorubicinloadedmagneticnanodrugsintargetedtherapyoflivercancer AT shuzhenshi studyontheapplicationofdoxorubicinloadedmagneticnanodrugsintargetedtherapyoflivercancer AT chaowang studyontheapplicationofdoxorubicinloadedmagneticnanodrugsintargetedtherapyoflivercancer |