Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway

Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway

IgA nephropathy (IgAN) is the most common primary glomerulonephritis and the main cause of end-stage renal disease (ESRD). Luteolin (Lut), which is present in various plants, has anti-inflammatory and antioxidant properties under numerous medical conditions. This study aimed to investigate the thera...

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Bibliographic Details
Main Authors: Dong-Yu Liang, Shao-Hua Cong, Lin-Hui Li, Qing-Qing Yi, Li-Ping Tang, Li-Ou Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
IgA nephropathy
ROS
extracellular matrix
Nrf-2
luteolin (LUT)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530655/full
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