Exercise-induced myokines in health and metabolic diseases

Skeletal muscle has been emerging as a research field since the past 2 decades. Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion, and expression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstal...

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Main Authors: Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Integrative Medicine Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213422014000705
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author Byunghun So
Hee-Jae Kim
Jinsoo Kim
Wook Song
author_facet Byunghun So
Hee-Jae Kim
Jinsoo Kim
Wook Song
author_sort Byunghun So
collection DOAJ
description Skeletal muscle has been emerging as a research field since the past 2 decades. Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion, and expression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine, or paracrine fashion. Myokines are recently recognized as potential candidates for treating metabolic diseases through their ability to stimulate AMP-activated protein kinase signaling, increase glucose uptake, and improve lipolysis. Myokines may have positive effects on metabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggested that myokines offer a potential treatment option for preventing metabolic diseases. This review summarizes the current understanding of the positive effects of exercise-induced myokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitory factor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, on metabolic diseases.
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series Integrative Medicine Research
spelling doaj-art-93d14f985b584fdfb6365ff527bc61542025-08-20T01:58:31ZengElsevierIntegrative Medicine Research2213-42202014-12-013417217910.1016/j.imr.2014.09.007Exercise-induced myokines in health and metabolic diseasesByunghun So0Hee-Jae Kim1Jinsoo Kim2Wook Song3Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, KoreaSkeletal muscle has been emerging as a research field since the past 2 decades. Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion, and expression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine, or paracrine fashion. Myokines are recently recognized as potential candidates for treating metabolic diseases through their ability to stimulate AMP-activated protein kinase signaling, increase glucose uptake, and improve lipolysis. Myokines may have positive effects on metabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggested that myokines offer a potential treatment option for preventing metabolic diseases. This review summarizes the current understanding of the positive effects of exercise-induced myokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitory factor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, on metabolic diseases.http://www.sciencedirect.com/science/article/pii/S2213422014000705exercisehealthmetabolic diseasesmyokines
spellingShingle Byunghun So
Hee-Jae Kim
Jinsoo Kim
Wook Song
Exercise-induced myokines in health and metabolic diseases
Integrative Medicine Research
exercise
health
metabolic diseases
myokines
title Exercise-induced myokines in health and metabolic diseases
title_full Exercise-induced myokines in health and metabolic diseases
title_fullStr Exercise-induced myokines in health and metabolic diseases
title_full_unstemmed Exercise-induced myokines in health and metabolic diseases
title_short Exercise-induced myokines in health and metabolic diseases
title_sort exercise induced myokines in health and metabolic diseases
topic exercise
health
metabolic diseases
myokines
url http://www.sciencedirect.com/science/article/pii/S2213422014000705
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AT heejaekim exerciseinducedmyokinesinhealthandmetabolicdiseases
AT jinsookim exerciseinducedmyokinesinhealthandmetabolicdiseases
AT wooksong exerciseinducedmyokinesinhealthandmetabolicdiseases